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Within macrophages, the brucellae route themselves to an intracellular compartment that is favourable for survival and replication, and they also appear to be well\u2010adapted from a physiological standpoint to withstand the environmental conditions encountered during prolonged residence in this intracellular niche. Much less is known about the interactions of the <jats:italic>Brucella<\/jats:italic> with placental trophoblasts, but experimental evidence suggests that these bacteria use an iron acquisition system to support extensive intracellular replication within these host cells that is not required for survival and replication in host macrophages. Thus, it appears that the brucellae rely upon the products of distinct subsets of genes to adapt successfully to the environmental conditions encountered within the two cell types within which they reside in their mammalian hosts.<\/jats:p>","DOI":"10.1111\/j.1365-2958.2004.04017.x","type":"journal-article","created":{"date-parts":[[2004,4,22]],"date-time":"2004-04-22T17:06:27Z","timestamp":1082653587000},"page":"621-630","source":"Crossref","is-referenced-by-count":95,"title":["Adaptation of the brucellae to their intracellular niche"],"prefix":"10.1111","volume":"52","author":[{"suffix":"II","given":"R. 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