{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T11:13:14Z","timestamp":1791976394392,"version":"4.4.0"},"reference-count":56,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2004,12,20]],"date-time":"2004-12-20T00:00:00Z","timestamp":1103500800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>Potato scab is a globally important disease caused by polyphyletic plant pathogenic <jats:italic>Streptomyces<\/jats:italic> species. <jats:italic>Streptomyces acidiscabies<\/jats:italic>, <jats:italic>Streptomyces scabies<\/jats:italic> and <jats:italic>Streptomyces turgidiscabies<\/jats:italic> possess a conserved biosynthetic pathway for the nitrated dipeptide phytotoxin thaxtomin. These pathogens also possess the <jats:italic>nec1<\/jats:italic> gene which encodes a necrogenic protein that is an independent virulence factor. In this article we describe a large (325\u2013660\u2003kb) pathogenicity island (PAI) conserved among these three plant pathogenic <jats:italic>Streptomyces<\/jats:italic> species. A partial DNA sequence of this PAI revealed the thaxtomin biosynthetic pathway, <jats:italic>nec1<\/jats:italic>, a putative tomatinase gene, and many mobile genetic elements. In addition, the PAI from <jats:italic>S. turgidiscabies<\/jats:italic> contains a plant fasciation (<jats:italic>fas<\/jats:italic>) operon homologous to and colinear with the <jats:italic>fas<\/jats:italic> operon in the plant pathogen <jats:italic>Rhodococcus fascians<\/jats:italic>. The PAI was mobilized during mating from <jats:italic>S. turgidiscabies<\/jats:italic> to the non\u2010pathogens <jats:italic>Streptomyces coelicolor<\/jats:italic> and <jats:italic>Streptomyces diastatochromogenes<\/jats:italic> on a 660\u2003kb DNA element and integrated site\u2010specifically into a putative integral membrane lipid kinase. Acquisition of the PAI conferred a pathogenic phenotype on <jats:italic>S. diastatochromogenes<\/jats:italic> but not on <jats:italic>S. coelicolor<\/jats:italic>. This PAI is the first to be described in a Gram\u2010positive plant pathogenic bacterium and is responsible for the emergence of new plant pathogenic <jats:italic>Streptomyces<\/jats:italic> species in agricultural systems.<\/jats:p>","DOI":"10.1111\/j.1365-2958.2004.04461.x","type":"journal-article","created":{"date-parts":[[2005,2,1]],"date-time":"2005-02-01T10:46:19Z","timestamp":1107254779000},"page":"1025-1033","source":"Crossref","is-referenced-by-count":190,"title":["A large, mobile pathogenicity island confers plant pathogenicity on <i>Streptomyces<\/i> species"],"prefix":"10.1111","volume":"55","author":[{"given":"Johan A.","family":"Kers","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kimberly D.","family":"Cameron","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Madhumita 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