{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,13]],"date-time":"2026-11-13T10:22:35Z","timestamp":1794565355689,"version":"4.9.1"},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T00:00:00Z","timestamp":1127952000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2005,11]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p>A strategy used by extracellular pathogens to evade phagocytosis is the utilization of exotoxins that kill host phagocytes. We have recently shown that one major pathogenicity strategy of <jats:italic>Photobacterium damselae<\/jats:italic> subsp. <jats:italic>piscicida<\/jats:italic> (<jats:italic>Phdp<\/jats:italic>), the agent of the widespread fish pasteurellosis, is the induction of extensive apoptosis of sea bass macrophages and neutrophils that results in lysis of these phagocytes by post\u2010apoptotic secondary necrosis. Here we show that this unique process is mediated by a novel plasmid\u2010encoded apoptosis inducing protein of 56\u2003kDa (AIP56), an exotoxin abundantly secreted by all virulent, but not avirulent, <jats:italic>Phdp<\/jats:italic> strains tested. AIP56 is related to an unknown protein of the enterohemorrhagic <jats:italic>Escherichia coli<\/jats:italic> O157:H7 and NleC, a <jats:italic>Citrobacter rodentium<\/jats:italic> type III secreted effector of unknown function. Passive immunization of sea bass with a rabbit anti\u2010AIP56 serum conferred protection against <jats:italic>Phdp<\/jats:italic> challenge, indicating that AIP56 represents a key virulence factor of that pathogen and is a candidate for the design of an anti\u2010pasteurellosis vaccine.<\/jats:p>","DOI":"10.1111\/j.1365-2958.2005.04893.x","type":"journal-article","created":{"date-parts":[[2005,9,29]],"date-time":"2005-09-29T09:44:06Z","timestamp":1127987046000},"page":"1025-1038","source":"Crossref","is-referenced-by-count":89,"title":["AIP56, a novel plasmid\u2010encoded virulence factor of <i>Photobacterium damselae<\/i> subsp. <i>piscicida<\/i> with apoptogenic activity against sea bass macrophages and neutrophils"],"prefix":"10.1111","volume":"58","author":[{"given":"Ana","family":"do Vale","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel T.","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuno M. 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