{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,29]],"date-time":"2026-10-29T18:21:50Z","timestamp":1793298110195,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T00:00:00Z","timestamp":1148601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Chlamydia trachomatis<\/jats:italic> is an obligate intracellular bacterium that causes a variety of diseases in humans. <jats:italic>C.\u2003trachomatis<\/jats:italic> has a complex developmental cycle that depends on host cells for replication, during which gene expression is tightly regulated. Here we identify two <jats:italic>C.\u2003trachomatis<\/jats:italic> proteases that possess deubiquitinating and deneddylating activities. We have designated these proteins <jats:italic>Chla<\/jats:italic>Dub1 and <jats:italic>Chla<\/jats:italic>Dub2. The genes encoding <jats:italic>Chla<\/jats:italic>Dub1 and <jats:italic>Chla<\/jats:italic>Dub2 are present in all <jats:italic>Chlamydia<\/jats:italic> species except for <jats:italic>Chlamydia pneumoniae<\/jats:italic>, and their catalytic domains bear similarity to the catalytic domains of other eukaryotic ubiquitin\u2010like proteases (Ulp). The <jats:italic>C.\u2003trachomatis<\/jats:italic> DUBs react with activity\u2010based probes and hydrolyse ubiquitinated and neddylated substrates. <jats:italic>Chla<\/jats:italic>Dub1 and <jats:italic>Chla<\/jats:italic>Dub2 represent the first known bacterial DUBs that possess both deubiquitinating and deneddylating activities.<\/jats:p>","DOI":"10.1111\/j.1365-2958.2006.05199.x","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T10:03:13Z","timestamp":1148637793000},"page":"142-150","source":"Crossref","is-referenced-by-count":140,"title":["<i>Chlamydia trachomatis<\/i>\u2010derived deubiquitinating enzymes in mammalian cells during infection"],"prefix":"10.1111","volume":"61","author":[{"given":"Shahram","family":"Misaghi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zarine 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