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Here, we show that a <jats:italic>Cryptococcus neoformans<\/jats:italic> Hsp70 homologue Ssa1 acts as a DNA\u2010binding transcriptional co\u2010activator of the fungal virulence factor, laccase, via binding to a GC\u2010rich element within the 5\u2032\u2010UAS in response to glucose starvation, iron, copper, calcium and temperature. In addition, Ssa1 forms a regulatory complex with heat shock transcription factor and TATA\u2010binding protein during laccase induction. Furthermore, deletion of Ssa1 results in reduced laccase and attenuated virulence using a mouse model. These results indicate that Hsp70 functions as a stress\u2010related transcriptional co\u2010activator required for fungal virulence.<\/jats:p>","DOI":"10.1111\/j.1365-2958.2006.05422.x","type":"journal-article","created":{"date-parts":[[2006,10,16]],"date-time":"2006-10-16T22:54:23Z","timestamp":1161039263000},"page":"1090-1101","source":"Crossref","is-referenced-by-count":59,"title":["The Hsp70 member, Ssa1, acts as a DNA\u2010binding transcriptional co\u2010activator of laccase in <i>Cryptococcus neoformans<\/i>"],"prefix":"10.1111","volume":"62","author":[{"given":"Shirong","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Moshe","family":"Hacham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Panepinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guowu","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soowan","family":"Shin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xudong","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter 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