{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:26:46Z","timestamp":1790249206781,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,9,25]],"date-time":"2006-09-25T00:00:00Z","timestamp":1159142400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2006,11]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Negative DNA supercoiling is an important conformational property of bacterial DNA that plays a significant role in a wide variety of DNA transactions. In contrast, positive DNA supercoiling is a by\u2010product of cellular processes that involve helical unwinding or movement of DNA by a fixed translocase, and has generally been considered a necessary evil requiring removal. We now report the first evidence suggesting a physiological role for positive supercoiling; this occurs in telomere resolution in the related Lyme disease and relapsing fever\n                    <jats:italic>Borrelia<\/jats:italic>\n                    spirochetes. Telomere resolution is the process whereby covalently closed hairpin telomeres are generated from replicative intermediates by the telomere resolvase, ResT. We observe a 20\u2010fold and greater stimulation of the reaction by positive supercoiling, which facilitates formation of a previously unobserved reaction intermediate. Our data suggest the possibility that the free energy of positive supercoiling, a resource with no previously described cellular function, may be harnessed and utilized as a regulator of post\u2010replication events.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2958.2006.05423.x","type":"journal-article","created":{"date-parts":[[2006,9,25]],"date-time":"2006-09-25T08:05:14Z","timestamp":1159171514000},"page":"895-905","source":"Crossref","is-referenced-by-count":28,"title":["Unexpected twist: harnessing the energy in positive supercoils to control telomere resolution"],"prefix":"10.1111","volume":"62","author":[{"given":"Troy","family":"Bankhead","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kerri","family":"Kobryn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George","family":"Chaconas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,25]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(02)00624-4"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0405762101"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.3603026"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817640.ch28"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04688.x"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2836(05)80272-4"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.186.11.3561-3569.2004"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1997.6051963.x"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2000.01698.x"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2005.04872.x"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817954.ch17"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/20.12.3229"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M409001200"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/35080005"},{"key":"e_1_2_6_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2004.04047.x"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2006.05245.x"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/37551"},{"key":"e_1_2_6_19_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.82.10.3078"},{"key":"e_1_2_6_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/9781555817954.ch20"},{"key":"e_1_2_6_21_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.22.7233-7239.1991"},{"key":"e_1_2_6_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0959-440X(92)90227-X"},{"key":"e_1_2_6_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(01)00433-6"},{"key":"e_1_2_6_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.02.025"},{"key":"e_1_2_6_25_1","doi-asserted-by":"publisher","DOI":"10.1006\/jmbi.1999.2805"},{"key":"e_1_2_6_26_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M504530200"},{"key":"e_1_2_6_27_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03640.x"},{"key":"e_1_2_6_28_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.20.7024"},{"key":"e_1_2_6_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.19.11163"},{"key":"e_1_2_6_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1104885"},{"key":"e_1_2_6_31_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.1999.01368.x"},{"key":"e_1_2_6_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1521-1878(199910)21:10<805::AID-BIES1>3.0.CO;2-7"},{"key":"e_1_2_6_33_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03382.x"},{"key":"e_1_2_6_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/emboj\/21.3.418"},{"key":"e_1_2_6_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.emboj.7600242"},{"key":"e_1_2_6_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb926"},{"key":"e_1_2_6_37_1","doi-asserted-by":"publisher","DOI":"10.1128\/AEM.70.10.5973-5979.2004"},{"key":"e_1_2_6_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)81717-9"},{"key":"e_1_2_6_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb08513.x"},{"key":"e_1_2_6_40_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2958.2003.03485.x"},{"key":"e_1_2_6_41_1","doi-asserted-by":"crossref","unstructured":"Tourand Y. 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