{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T12:47:02Z","timestamp":1792414022273,"version":"4.4.0"},"reference-count":69,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,12,6]],"date-time":"2006-12-06T00:00:00Z","timestamp":1165363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p> <jats:italic>Borrelia burgdorferi<\/jats:italic> survives in an enzootic cycle, and Dps proteins protect DNA against damage during starvation or oxidative stress. The role of a Dps homologue encoded by Borrelia in spirochaete survival was assessed. Dps\u2010deficient spirochaetes were infectious in mice via needle\u2010inoculation at the dose of 10<jats:sup>5<\/jats:sup> spirochaetes. Larval ticks successfully acquired Dps\u2010deficient spirochaetes via a blood meal on mice. However, after extended periods within unfed nymphs, the Dps\u2010deficient spirochaetes failed to be transmitted to a new host when nymphs fed. Our data suggest that Dps functions to protect the spirochaetes during dormancy in unfed ticks, and in its absence, the spirochaetes become susceptible during tick feeding. <jats:italic>dps<\/jats:italic> is differentially expressed <jats:italic>in vivo<\/jats:italic>\u2013 low in mice and high in ticks \u2013 but constitutively expressed <jats:italic>in vitro<\/jats:italic>, showing little change during growth or in response to oxidative stress. Borrelia Dps forms a dodecameric complex capable of sequestering iron. The Dps\u2010deficient spirochaetes showed no defect in starvation and oxidative stress assays, perhaps due to the lack of iron in spirochaetes grown <jats:italic>in vitro<\/jats:italic>. Dps is critical for spirochaete persistence within ticks, and strategies to interfere with Dps could potentially reduce Borrelia populations in nature and thereby influence the incidence of Lyme disease.<\/jats:p>","DOI":"10.1111\/j.1365-2958.2006.05550.x","type":"journal-article","created":{"date-parts":[[2006,12,21]],"date-time":"2006-12-21T06:04:48Z","timestamp":1166681088000},"page":"694-710","source":"Crossref","is-referenced-by-count":101,"title":["The Lyme disease agent <i>Borrelia burgdorferi<\/i> requires BB0690, a Dps homologue, to persist within ticks"],"prefix":"10.1111","volume":"63","author":[{"given":"Xin","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Utpal","family":"Pal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nandhini","family":"Ramamoorthi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel C.","family":"Desrosiers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"ChristiaN. 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