{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T11:15:06Z","timestamp":1789816506469,"version":"4.0.1"},"reference-count":50,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2007,5,30]],"date-time":"2007-05-30T00:00:00Z","timestamp":1180483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2007,6]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Plague, or the Black Death, is a zoonotic disease that is spread from mammal to mammal by fleas. This mode of transmission demands that the causative agent of this disease,\n                    <jats:italic>Yersinia pestis<\/jats:italic>\n                    , is able to survive and multiply in both mammals and insects. In recent years the complete genome sequence of a number of\n                    <jats:italic>Y.\u2003pestis<\/jats:italic>\n                    strains have been determined. This sequence information indicates that\n                    <jats:italic>Y.\u2003pestis<\/jats:italic>\n                    contains a cluster of genes with homology to insecticidal toxin encoding genes of the insect pathogen\n                    <jats:italic>Photorhabdus luminescens<\/jats:italic>\n                    . Here we demonstrate that\n                    <jats:italic>Y.\u2003pestis<\/jats:italic>\n                    KIM strains produced the encoded proteins. Production of the locus\u2010encoded proteins was dependent on a gene (\n                    <jats:italic>yitR<\/jats:italic>\n                    ) encoding a member of the LysR family of transcriptional activators. Evidence suggests the proteins are type III secretion substrates. N terminal amino acids (100 to 367) of each protein fused to an epitope tag were secreted by the virulence plasmid type III secretion type. A fusion protein comprised of the N\u2010terminus of YipB and the enzymatic active component of\n                    <jats:italic>Bordetella pertussis<\/jats:italic>\n                    adenylate cyclase (Cya) was translocated into both mammalian and insect cells. In conclusion, a new class of\n                    <jats:italic>Y.\u2003pestis<\/jats:italic>\n                    type III secreted and translocated proteins has been identified. We hypothesize that these proteins function to promote transmission of and infection by\n                    <jats:italic>Y.\u2003pestis<\/jats:italic>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2958.2007.05729.x","type":"journal-article","created":{"date-parts":[[2007,5,31]],"date-time":"2007-05-31T01:26:24Z","timestamp":1180574784000},"page":"1214-1227","source":"Crossref","is-referenced-by-count":41,"title":["Identification and type III\u2010dependent secretion of the\n                    <i>Yersinia pestis<\/i>\n                    insecticidal\u2010like proteins"],"prefix":"10.1111","volume":"64","author":[{"given":"Inessa","family":"Gendlina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiara G.","family":"Held","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Schesser Bartra","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Byron M.","family":"Gallis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin E.","family":"Doneanu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David R.","family":"Goodlett","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory V.","family":"Plano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carleen 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