{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T19:09:39Z","timestamp":1791227379905,"version":"4.1.0"},"reference-count":47,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2011,12,20]],"date-time":"2011-12-20T00:00:00Z","timestamp":1324339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2012,1]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>\n                    Bloodstream infection with\n                    <jats:italic>Staphylococcus aureus<\/jats:italic>\n                    is common and can be fatal. However, virulence factors that contribute to lethality in\n                    <jats:italic>S.\u2003aureus<\/jats:italic>\n                    bloodstream infection are poorly defined. We discovered that LukED, a commonly overlooked leucotoxin, is critical for\n                    <jats:italic>S.\u2003aureus<\/jats:italic>\n                    bloodstream infection in mice. We also determined that LukED promotes\n                    <jats:italic>S.\u2003aureus<\/jats:italic>\n                    replication\n                    <jats:italic>in vivo<\/jats:italic>\n                    by directly killing phagocytes recruited to sites of haematogenously seeded tissue. Furthermore, we established that murine neutrophils are the primary target of LukED, as the greater virulence of wild\u2010type\n                    <jats:italic>S.\u2003aureus<\/jats:italic>\n                    compared with a\n                    <jats:italic>lukED<\/jats:italic>\n                    mutant was abrogated by depleting neutrophils. The\n                    <jats:italic>in vivo<\/jats:italic>\n                    toxicity of LukED towards murine phagocytes is unique among\n                    <jats:italic>S.\u2003aureus<\/jats:italic>\n                    leucotoxins, implying its crucial role in pathogenesis. Moreover, the tropism of LukED for murine phagocytes highlights the utility of murine models to study LukED pathobiology, including development and testing of strategies to inhibit toxin activity and control bacterial infection.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2958.2011.07942.x","type":"journal-article","created":{"date-parts":[[2011,12,6]],"date-time":"2011-12-06T07:25:30Z","timestamp":1323156330000},"page":"423-435","source":"Crossref","is-referenced-by-count":147,"title":["<i>Staphylococcus aureus<\/i>\n                    leucocidin ED contributes to systemic infection by targeting neutrophils and promoting bacterial growth\n                    <i>in vivo<\/i>"],"prefix":"10.1111","volume":"83","author":[{"given":"Francis","family":"Alonzo III","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meredith A.","family":"Benson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard P.","family":"Novick","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Shopsin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor J.","family":"Torres","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2011,12,20]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/JB.01000-07"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plasmid.2005.05.005"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2011.07720.x"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100001"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-64-2-328"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.423507"},{"key":"e_1_2_6_8_1","first-page":"992","article-title":"Methicillin\u2010resistant Staphylococcus aureus infections in correctional facilities \u2013 Georgia, California, and Texas, 2001\u20132003","volume":"52","author":"Center for Disease Control and Prevention (CDC)","year":"2003","journal-title":"MMWR Morb Mortal Wkly Rep"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005792-197903000-00002"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.0407247"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1086\/503777"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912403107"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2958.2010.07490.x"},{"key":"e_1_2_6_14_1","first-page":"95","article-title":"Staphylococcal coagulase; 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