{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T22:13:05Z","timestamp":1759615985652},"reference-count":18,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2012,5,30]],"date-time":"2012-05-30T00:00:00Z","timestamp":1338336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Molecular Microbiology"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Summary<\/jats:title><jats:p><jats:italic>Brucella<\/jats:italic> strains encounter oxygen deprivation during their intracellular replication in host cells, and the capacity of these bacteria to utilize NO<jats:sub>3<\/jats:sub> as an alternative electron acceptor for respiration plays an important role in their successful adaption to their intracellular niche. In this issue of <jats:italic>Molecular Microbiology<\/jats:italic>, <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"#b3\">Carrica <jats:italic>et\u2003al<\/jats:italic> (2012<\/jats:ext-link>). report that NtrY and NtrX comprise a redox\u2010responsive two\u2010component regulator in <jats:italic>Brucella abortus<\/jats:italic> 2308 that responds to decreasing levels of O<jats:sub>2<\/jats:sub> and induces the expression of this strain's denitrification genes. Thus, NtrYX joins the increasing number of genetic regulators that contribute to the metabolic versatility required for the virulence of <jats:italic>Brucella<\/jats:italic> strains in their mammalian hosts.<\/jats:p>","DOI":"10.1111\/j.1365-2958.2012.08096.x","type":"journal-article","created":{"date-parts":[[2012,5,14]],"date-time":"2012-05-14T22:05:41Z","timestamp":1337033141000},"page":"5-7","source":"Crossref","is-referenced-by-count":10,"title":["Redox\u2010responsive regulation of denitrification genes in <i>Brucella<\/i>"],"prefix":"10.1111","volume":"85","author":[{"given":"R. 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