{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,19]],"date-time":"2025-10-19T05:51:45Z","timestamp":1760853105490},"reference-count":58,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,1,4]],"date-time":"2005-01-04T00:00:00Z","timestamp":1104796800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> Serotonin (5\u2010HT) plays an important role in the pathophysiology of irritable bowel syndrome (IBS). Using <jats:italic>\u03b1<\/jats:italic>\u2010[<jats:sup>11<\/jats:sup>C]methyl\u2010<jats:sc>l<\/jats:sc>\u2010tryptophan\u2010positron emission tomography (PET), it was demonstrated that brain 5\u2010HT synthesis is increased in patients with IBS, in a gender\u2010specific manner. The aims of the study were to evaluate the effects of alosetron on brain 5\u2010HT synthesis in patients with IBS. Six male and five female non\u2010constipation\u2010predominant IBS patients were enrolled. The subjects received alosetron or a placebo for 14\u2003days, separated by a 2\u2010week washout period. On day 14, rectal distensions commenced just prior to the PET scan (which was performed for 80\u2003min), and continued for 20\u2010min periods. The functional images were analysed with SPM99. Alosetron <jats:italic>vs<\/jats:italic> placebo treatments, in a randomized, double\u2010blinded, crossover manner, were studied. 5\u2010HT synthesis was greater in several regions in the males than in the females during the alosetron treatment, whereas there was no region in which the females had greater synthesis. There were significant gender\u2010treatment interactions of synthesis in the cingulate gyrus, caudate nucleus, globus pallidus, and cerebellum. The gender differences in the effect of alosetron on brain 5\u2010HT synthesis may be related to the gender differences in the efficacy of alosetron.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2004.00615.x","type":"journal-article","created":{"date-parts":[[2005,3,19]],"date-time":"2005-03-19T12:41:00Z","timestamp":1111236060000},"page":"212-221","source":"Crossref","is-referenced-by-count":21,"title":["The effects of the 5\u2010HT<sub>3<\/sub> antagonist, alosetron, on brain serotonin synthesis in patients with irritable bowel 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