{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T20:52:58Z","timestamp":1788900778879,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2005,3,18]],"date-time":"2005-03-18T00:00:00Z","timestamp":1111104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2005,4]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold><jats:bold> Background:\u2002<\/jats:bold> Recent studies suggest that duodeno\u2010gastro\u2010oesophageal reflux (DGER) contributes to the occurrence of reflux oesophagitis and Barrett's oesophagus. The mechanisms underlying duodeno\u2010gastric reflux (DGR), a prerequisite for DGER, are poorly understood.<\/jats:p><jats:p><jats:bold>Aims:\u2002<\/jats:bold> To study the occurrence of DGR in relation to interdigestive and postprandial gastroduodenal motility.<\/jats:p><jats:p><jats:bold>Subjects and methods:\u2002<\/jats:bold> Ten healthy subjects underwent stationary gastroduodenal manometry with simultaneous duodenal and antral Bilitec<jats:sup>\u00ae<\/jats:sup> recording 4\u2003h before and 5\u2003h after ingestion of a liquid meal. Eight volunteers underwent the same study, with administration of erythromycin postprandially.<\/jats:p><jats:p><jats:bold>Results:\u2002<\/jats:bold> During the interdigestive phase II, all volunteers had short DGR episodes. Postprandially, DGR occurred in all subjects, on average 39\u2003\u00b1\u200328\u2003min after the start of the meal, and was cleared from the stomach after 242\u2003\u00b1\u200323\u2003min. Induction of increased antral motility and of a premature phase III, by administration of erythromycin, was associated with faster gastric DGR clearance. However, there was no direct temporal relationship between erythromycin\u2010induced gastric phase III and erythromycin\u2010induced DGR clearance.<\/jats:p><jats:p><jats:bold>Conclusion:\u2002<\/jats:bold> In healthy subjects, duodenogastric reflux occurs sporadically in the interdigestive state and is a normal phenomenon in the postprandial period. Erythromycin induces faster clearance of DGR from the stomach, which depends on enhanced antral contractile activity rather than premature phase III.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2004.00633.x","type":"journal-article","created":{"date-parts":[[2005,3,19]],"date-time":"2005-03-19T12:41:00Z","timestamp":1111236060000},"page":"191-199","source":"Crossref","is-referenced-by-count":38,"title":["Mechanisms underlying duodeno\u2010gastric reflux in man"],"prefix":"10.1111","volume":"17","author":[{"given":"G. 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