{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T12:47:10Z","timestamp":1770814030120,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2005,2,3]],"date-time":"2005-02-03T00:00:00Z","timestamp":1107388800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2005,6]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> This work was performed to study electrically induced contractions in the descending colon of pigs. Contractions were monitored using impedance planimetry and manometry. The luminal pressure, cross\u2010sectional area (CSA), latency and velocity of CSA decrease were compared when using 3\u2003ms, 9, 12, 15 or 30\u2003mA pulses at 10\u2003Hz for 10\u2003s, and 15\u2003mA, 0.03, 0.3 or 3\u2003ms pulses at 10\u2003Hz for 10\u2003s. Stimulation was performed prior and after the application of <jats:italic>N<\/jats:italic>(G)\u2010nitro\u2010<jats:sc>l<\/jats:sc>\u2010<jats:italic>arginine methyl ester<\/jats:italic> (<jats:sc>l<\/jats:sc>\u2010<jats:italic>NAME<\/jats:italic>) and atropine. In the untreated colon, contraction was always of an \u2018off\u2019 type. A current increase from 9 to 30\u2003mA increased the pressure. An increase of pulse duration from 0.03 to 3\u2003ms shortened the latency, accelerated contraction and increased pressure. By sequential stimulation, contractions were coordinated to propel semi\u2010fluid and solid luminal contents. <jats:sc><jats:italic>l<\/jats:italic><\/jats:sc>\u2010<jats:italic>NAME increased the magnitude of CSA decrease. Atropine induced inhibitory effects on contractions elicited by 3\u2003ms pulses and abolished contractions induced by 0.03 and 0.3\u2003ms pulses. In conclusion: (i) electrical stimulation evokes<\/jats:italic>\u2018off\u2019 colon contractions, which can be coordinated to result in propulsion; (ii) the best combination for current and pulse duration to induce propulsive contractions is 15\u2003mA and 3\u2003ms; (iii) nitrergic and cholinergic pathways mediate responses to electrical stimulation.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2004.00637.x","type":"journal-article","created":{"date-parts":[[2005,5,25]],"date-time":"2005-05-25T02:14:46Z","timestamp":1116987286000},"page":"376-387","source":"Crossref","is-referenced-by-count":28,"title":["Propulsive activity induced by sequential electrical stimulation in the descending colon of the pig"],"prefix":"10.1111","volume":"17","author":[{"given":"C.","family":"Sevcencu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. J. 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