{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:04:23Z","timestamp":1792800263467,"version":"4.5.0"},"reference-count":38,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T00:00:00Z","timestamp":1140998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2006,7]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> The objective of this study was to determine whether or not the number of enteroendocrine cells (ECs) in the gut is related to visceral hypersensitivity in patients with diarrhoea\u2010predominant irritable bowel syndrome (D\u2010IBS). Twenty\u2010five subjects with D\u2010IBS (mean, 43.1\u2003years; 16 women, nine men) were recruited into our study, along with 13 healthy controls (mean, 40.7\u2003years; nine women, four men). Maximally tolerable pressures were evaluated via barostat testing, and the levels of ECs were immunohistochemically identified and quantified via image analysis. The numbers of ECs between the D\u2010IBS subjects and the controls were not significantly different in the terminal ileum, ascending colon and rectum. However, the maximally tolerable pressures determined in the D\u2010IBS subjects were significantly lower than those of the control subjects (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01), and we detected a significant relationship between the maximally tolerable pressures and the numbers of ECs in the rectum (<jats:italic>r<\/jats:italic>\u2003=\u2003\u22120.37, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.01). Rectal sensitivity was enhanced to a greater degree in D\u2010IBS patients exhibiting an elevated level of rectal ECs. This study provides some evidence to suggest that ECs play an important role in visceral hypersensitivity.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00771.x","type":"journal-article","created":{"date-parts":[[2006,2,27]],"date-time":"2006-02-27T17:02:14Z","timestamp":1141059734000},"page":"539-546","source":"Crossref","is-referenced-by-count":71,"title":["Enteroendocrine cell counts correlate with visceral hypersensitivity in patients with diarrhoea\u2010predominant irritable bowel syndrome"],"prefix":"10.1111","volume":"18","author":[{"given":"J. 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