{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:51:38Z","timestamp":1790707898086,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T00:00:00Z","timestamp":1148601600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> Clinical studies reveal concomitant occurrence of several gastrointestinal and urologic disorders, including irritable bowel syndrome and interstitial cystitis. The purpose of this study was to determine the mechanisms underlying cross\u2010organ sensitization at the level of dorsal root ganglion (DRG) after acute and subsided gastrointestinal inflammation. DiI (1,1\u2032\u2010dioctadecyl\u20103,3,3\u2032,3\u2032\u2010tetramethylindocarbocyanine perchlorate) and Fast Blue were injected into the distal colon and urinary bladder of male rats, respectively. Convergent DRG neurons were found in L1\u2010L3 and L6\u2010S2 ganglia with an average distribution of 14%\u2003\u00b1\u20032%. The resting membrane potential (RMP) of cells isolated from upper lumbar (UL) ganglia was \u221259.8\u2003\u00b1\u20032.7\u2003mV, whereas lumbosacral (LS) neurons were more depolarized (RMP\u2003=\u2003\u221249.4\u2003\u00b1\u20032.1\u2003mV, <jats:italic>P<\/jats:italic>\u2003\u2264\u20030.05) under control conditions. Acute trinitrobenzene sulfonic acid (TNBS) colitis (3\u2003days) decreased voltage and current thresholds for action potential firing in LS but not UL convergent capsaicin\u2010sensitive neurons. This effect persisted for 30\u2003days in the absence of overt colonic inflammation. The current threshold for action potential (AP) firing in UL cells was also decreased from 165.0\u2003\u00b1\u200324.5\u2003pA (control) to 85.0\u2003\u00b1\u200319.1\u2003pA at 30\u2003days (<jats:italic>P<\/jats:italic>\u2003\u2264\u20030.05), indicating increased excitability. The presence of a subpopulation of colon\u2010bladder convergent DRG neurons and their persistent hyperexcitability after colonic inflammation provides a basis for pelvic organ cross\u2010sensitization.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00807.x","type":"journal-article","created":{"date-parts":[[2006,5,26]],"date-time":"2006-05-26T14:30:45Z","timestamp":1148653845000},"page":"936-948","source":"Crossref","is-referenced-by-count":121,"title":["Hyperexcitability of convergent colon and bladder dorsal root ganglion neurons after colonic inflammation: mechanism for pelvic organ cross\u2010talk"],"prefix":"10.1111","volume":"18","author":[{"given":"A. 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