{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T10:36:04Z","timestamp":1790678164983,"version":"4.1.0"},"reference-count":24,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,11,24]],"date-time":"2006-11-24T00:00:00Z","timestamp":1164326400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> Systemic sclerosis is a connective tissue disease that involves the gastrointestinal (GI) tract. Seventy\u2010five per cent of systemic sclerosis patients experience symptoms arising from oesophagus. The intestine has less frequently been subject for studies than the oesophagus. When the small intestine becomes involved, nausea, vomiting, bloating, diarrhoea and malabsorption may occur. Previous studies have shown decreased and abnormal intestinal motility, dilatation and a stiffer wall. The aim was to study muscle mechanics in systemic sclerosis patients using novel analysis of intestinal muscle contraction force\u2013velocity and power. A volume\u2010controlled duodenal ramp\u2010distension protocol was used in nine patients and eight healthy controls. The wall stretch ratio, tension, shortening velocity and muscle power were computed from pressure and cross\u2010sectional area data recorded by an impedance planimetry system. The tension\u2013stretch ratio relation obtained in patients was shifted to the left, indicating a stiffer wall. The <jats:italic>in vivo<\/jats:italic> tension\u2010shortening velocity relationship was quantified using Hill's equation. The maximum preload tension (tension at zero velocity) was lower in the patients than in the healthy controls (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). The muscle power was lowest in the patients. An association was found between the duration of the disease and the maximum stretch ratio (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05). The study represents the first data with application of <jats:italic>in vivo<\/jats:italic> muscle force\u2013velocity relations in patients with gastrointestinal diseases. Systemic sclerosis patients had increased stiffness and impaired muscle dynamics of the duodenum. Decreased muscle function and increased wall stiffness may explain the GI symptoms reported in this patient group.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00837.x","type":"journal-article","created":{"date-parts":[[2006,11,24]],"date-time":"2006-11-24T09:14:57Z","timestamp":1164359697000},"page":"11-19","source":"Crossref","is-referenced-by-count":28,"title":["A new method for evaluation of intestinal muscle contraction properties: studies in normal subjects and in patients with systemic sclerosis"],"prefix":"10.1111","volume":"19","author":[{"given":"H.","family":"Gregersen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Liao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Pedersen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. M.","family":"Drewes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(88)70070-5"},{"key":"e_1_2_5_3_2","doi-asserted-by":"crossref","first-page":"130","DOI":"10.2340\/0001555580134135","article-title":"Oesophageal manometry and video\u2010radiology in patients with systemic sclerosis: a retrospective study of its clinical value","volume":"80","author":"Ipsen P","year":"2000","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018831104549"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2001.00259.x"},{"key":"e_1_2_5_6_2","first-page":"371","article-title":"Esophageal and small intestinal manifestations of progressive systemic sclerosis. A clinical and experimental study","volume":"41","author":"Hendel L","year":"1994","journal-title":"Dan Med Bull"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1998.00334.x"},{"key":"e_1_2_5_8_2","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/S0016-5085(82)80192-3","article-title":"Interdigestive motor activity in patients with systemic sclerosis","volume":"83","author":"Rees WD","year":"1982","journal-title":"Gastroenterology"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(80)90091-8"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(69)90044-8"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00265-8"},{"key":"e_1_2_5_12_2","first-page":"202","article-title":"Scleroderma (systemic sclerosis): classification, subsets and pathogenesis","volume":"15","author":"LeRoy EC","year":"1988","journal-title":"J Rheumatol"},{"key":"e_1_2_5_13_2","first-page":"G26","article-title":"Variations in duodenal cross\u2010sectional area during the interdigestive migrating motility complex","volume":"259","author":"Gregersen H","year":"1990","journal-title":"Am J Physiol"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00341.x"},{"key":"e_1_2_5_15_2","first-page":"G795","article-title":"Biomechanical properties of duodenal wall and duodenal tone during phase I and phase II of the MMC","volume":"263","author":"Gregersen H","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00496.2001"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00456.2001"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520310000401"},{"key":"e_1_2_5_19_2","volume-title":"Biomechanics of the Gastrointestinal Tract","author":"Gregersen H.","year":"2002"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.1996.tb00267.x"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107387"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1002\/mus.10271"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)91176-5"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00134.2001"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(79)90218-X"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2982.2006.00837.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2982.2006.00837.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T20:49:44Z","timestamp":1696970984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2982.2006.00837.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,7]]},"references-count":24,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1]]}},"alternative-id":["10.1111\/j.1365-2982.2006.00837.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2982.2006.00837.x","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,7]]}}}