{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T21:37:43Z","timestamp":1776893863382,"version":"3.51.2"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2007,3]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> Recent studies indicate that impaired meal accommodation or hypersensitivity to distention are highly prevalent in adult functional dyspepsia (FD). Our aim was to investigate whether similar abnormalities also occur in paediatric FD. Sixteen FD patients (15 girls, 10\u201316\u2003years) were studied. The severity (0\u20133; 0, absent; 3, severe) of eight dyspeptic symptoms (epigastric pain, fullness, bloating, early satiety, nausea, vomiting, belching and epigastric burning) and the amount of weight loss were determined by questionnaire. All children underwent a gastric barostat study after an overnight fast to determine sensitivity to distention and meal\u2010induced accommodation, which were compared with normal values in young adults (18\u201322\u2003years). On a separate day, all patients underwent a gastric emptying breath test. A mean weight loss of 4.8\u2003\u00b1\u20030.9\u2003kg was present in 14 children. Compared with controls, patients had lower discomfort thresholds to gastric distention (8.8\u2003\u00b1\u20031.0\u2003mmHg <jats:italic>vs<\/jats:italic> 13.9\u2003\u00b1\u20031.9\u2003mmHg, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.02) and gastric accommodation (87\u2003\u00b1\u200325\u2003mL <jats:italic>vs<\/jats:italic> 154\u2003\u00b1\u200320\u2003mL <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.04). Hypersensitivity to distention and impaired accommodation were present in respectively nine (56%) and 11 (69%) patients. No relationship was found between barostat and gastric emptying, which was delayed in only three patients. The majority of children with unexplained epigastric symptoms have abnormalities of gastric sensorimotor function.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00850.x","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T12:35:49Z","timestamp":1161088549000},"page":"173-179","source":"Crossref","is-referenced-by-count":31,"title":["Assessment of gastric sensorimotor function in paediatric patients with unexplained dyspeptic symptoms and poor weight gain"],"prefix":"10.1111","volume":"19","author":[{"given":"I.","family":"Hoffman","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Vos","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.","family":"Tack","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,10,17]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1136\/gut.45.2008.ii37","article-title":"Functional gastroduodenal disorders","volume":"45","author":"Talley NJ","year":"1999","journal-title":"Gut"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1996.v110.pm8612991"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2003.07389.x"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05264.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.27180"},{"issue":"2","key":"e_1_2_5_8_2","first-page":"1160","article-title":"Childhood functional gastrointestinal disorders","volume":"45","author":"Rasquin\u2010Weber A","year":"1999","journal-title":"Gut"},{"key":"e_1_2_5_9_2","first-page":"256","article-title":"Gastric emptying of solids in children with H. pylori\u2010positive and H. pylori\u2010negative non\u2010ulcer dyspepsia","volume":"39","author":"Sykora J","year":"2004","journal-title":"JPGN"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1067\/S0022-3476(03)00504-3"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005493123557"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1067\/mpd.2001.118883"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2004.11.031"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199608000-00003"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90057-8"},{"key":"e_1_2_5_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.MPG.0000154661.39488.AC"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(96)70246-9"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200004000-00012"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199907000-00013"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1177\/000992280304200708"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.1.e1"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2004-2497"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010793408132"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2005.00624.x"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.9.1271"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2002.00326.x"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-200208000-00017"},{"issue":"4","key":"e_1_2_5_29_2","first-page":"iv 34","article-title":"Non\u2010invasive investigation of gastrointestinal functions with magnetic resonance imaging: towards an \u2018\u2018ideal\u2019\u2019 investigation of gastrointestinal function","volume":"52","author":"Schwizer W","year":"2003","journal-title":"Gut"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.277.6.G1217"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00431.x"}],"container-title":["Neurogastroenterology &amp; 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