{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,10]],"date-time":"2026-10-10T13:40:52Z","timestamp":1791639652466,"version":"4.3.4"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T00:00:00Z","timestamp":1161043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> The G protein\u2010coupled receptors, GPR41 and GPR43, are activated by short\u2010chain fatty acids (SCFAs), with distinct rank order potencies. This study investigated the possibility that SCFAs modulate intestinal motility via these receptors. Luminal SCFA concentrations within the rat intestine were greatest in the caecum (<jats:italic>c<\/jats:italic>. 115\u2003mmol\u2003L<jats:sup>\u22121<\/jats:sup>) and proximal colon. Using similar concentrations (0.1\u2013100\u2003mmol\u2003L<jats:sup>\u22121<\/jats:sup>), SCFAs were found to inhibit electrically evoked, neuronally mediated contractions of rat distal colon, possibly via a prejunctional site of action; this activity was independent of the presence or absence of the mucosa. By contrast, SCFAs reduced the amplitude but also reduced the threshold and increased the frequency of peristaltic contractions in guinea\u2010pig terminal ileum. In each model, the rank\u2010order of activity was acetate (C2) \u2248 propionate (C3) \u2248 butyrate (C4) &gt; pentanoate (C5) \u223c formate (C1), consistent with activity at the GPR43 receptor. GPR43 mRNA was expressed throughout the rat gut, with highest levels in the colon. However, the ability of SCFAs to inhibit neuronally mediated contractions of the colon was similar in tissues from wild\u2010type and GPR43 gene knockout mice, with identical rank\u2010orders of potency. In conclusion, SCFAs can modulate intestinal motility, but these effects can be independent of the GPR43 receptor.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00853.x","type":"journal-article","created":{"date-parts":[[2006,10,17]],"date-time":"2006-10-17T12:35:49Z","timestamp":1161088549000},"page":"66-74","source":"Crossref","is-referenced-by-count":153,"title":["The relationship between the effects of short\u2010chain fatty acids on intestinal motility <i>in vitro<\/i> and GPR43 receptor activation"],"prefix":"10.1111","volume":"19","author":[{"given":"N. B.","family":"Dass","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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