{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T08:14:20Z","timestamp":1790151260354,"version":"4.0.1"},"reference-count":64,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T00:00:00Z","timestamp":1160524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> Functional dyspepsia (FD) is a highly prevalent gastrointestinal disorder and has a complex pathophysiology. Impaired fundic relaxation in response to a meal is present in 40% of patients with FD. This review focuses on impaired gastric accommodation of the stomach as a pathophysiological mechanism and the possible therapeutic targets that can be derived from the current knowledge of the neuroregulation of the accommodation reflex. First the different means of gastric accommodation assessment are described and the relationship between symptoms and impaired gastric accommodation. The different therapeutic options are subsequently discussed in view of their molecular target, based on the different receptor subtypes involved in the accommodation reflex. Although impaired gastric accommodation is highly prevalent in dyspeptic patients and basic knowledge about the accommodation reflex enables to develop pathophysiologically targeted therapies, it is unlikely that therapies aimed at dysaccommodation of the stomach will lead to symptom relief in all dyspeptic patients. A major challenge is the development of methods that readily identify impaired accommodation in clinical practice.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00863.x","type":"journal-article","created":{"date-parts":[[2006,10,11]],"date-time":"2006-10-11T20:46:56Z","timestamp":1160599616000},"page":"85-93","source":"Crossref","is-referenced-by-count":39,"title":["Dysaccommodation of the stomach: therapeutic nirvana?"],"prefix":"10.1111","volume":"19","author":[{"given":"R.","family":"Bisschops","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Tack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,12,7]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii37"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.05.030"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2005.04.001"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2000.00868.x"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00497.x"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90967-X"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03520.x"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01775.x"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-005-2911-3"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.7863\/jum.1995.14.2.81"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529709000193"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2982.2003.00431.x"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.277.6.G1217"},{"key":"e_1_2_5_15_2","first-page":"147","article-title":"Noninvasive measurement of gastric accommodation by means of pertechnate SPECT: limiting radiation dose without losing image quality","volume":"45","author":"Bennink RJ","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_5_16_2","first-page":"1155","article-title":"Simultaneous assessment of gastric accommodation and emptying studies with liquid and solid meals","volume":"45","author":"Simonian HP","year":"2004","journal-title":"J Nucl Med"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.2001.280.6.G1227"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1522-2586(199901)9:1<75::AID-JMRI10>3.0.CO;2-I"},{"key":"e_1_2_5_19_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.52.9.1271"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2001.28656"},{"key":"e_1_2_5_21_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.34022"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(00)84816-7"},{"key":"e_1_2_5_23_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00588.x"},{"key":"e_1_2_5_24_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.08.020"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00361.2002"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.35.3.327"},{"key":"e_1_2_5_27_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02213124"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(98)70012-5"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00153-9"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.05264.x"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.05421.x"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(03)00130-7"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90266-X"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00456.2002"},{"key":"e_1_2_5_35_2","first-page":"1","article-title":"Influence of motilin on gastric fundus tone and on meal\u2010induced satiety in man: role of cholinergic pathways","volume":"100","author":"Cuomo R","year":"2005","journal-title":"Am J Gastroenterol"},{"key":"e_1_2_5_36_2","first-page":"G727","article-title":"Vagally mediated gastric relaxation induced by intestinal nutrients in the dog","volume":"251","author":"Azpiroz F","year":"1986","journal-title":"Am J Physiol"},{"key":"e_1_2_5_37_2","first-page":"G595","article-title":"Reflex gastric relaxation in response to distention of the duodenum","volume":"252","author":"De Ponti F","year":"1987","journal-title":"Am J Physiol"},{"key":"e_1_2_5_38_2","doi-asserted-by":"publisher","DOI":"10.1038\/351477a0"},{"key":"e_1_2_5_39_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.212"},{"key":"e_1_2_5_40_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.51.2.219"},{"key":"e_1_2_5_41_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(03)00287-7"},{"key":"e_1_2_5_42_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.025031"},{"key":"e_1_2_5_43_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v11.i31.4848"},{"key":"e_1_2_5_44_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.1999.276.2.G373"},{"key":"e_1_2_5_45_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018839122354"},{"key":"e_1_2_5_46_2","doi-asserted-by":"publisher","DOI":"10.2174\/1568010054526359"},{"key":"e_1_2_5_47_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00419.2003"},{"key":"e_1_2_5_48_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2003.01469.x"},{"key":"e_1_2_5_49_2","first-page":"1077","article-title":"The influence of cisapride on gastric tone and the perception of gastric distension","volume":"11","author":"Tack J","year":"1997","journal-title":"Aliment Pharmacol Ther"},{"key":"e_1_2_5_50_2","first-page":"A20","article-title":"A phase II trial with tegaserod in functional dyspepsia patients with normal gastric emptying (abstr)","volume":"120","author":"Tack J","year":"2002","journal-title":"Gastroenterology"},{"key":"e_1_2_5_51_2","first-page":"A94","article-title":"Effect of tegaserod, a 5\u2010HT4 receptor agonist, on sensory and motor function of the proximal stomach in functional dyspepsia","volume":"128","author":"Tack J","year":"2005","journal-title":"Gastroenterology"},{"key":"e_1_2_5_52_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.46.4.468"},{"key":"e_1_2_5_53_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010670030067"},{"key":"e_1_2_5_54_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0928-0987(97)00073-0"},{"key":"e_1_2_5_55_2","first-page":"A325","article-title":"A placebo\u2010controlled trial of buspirone, a fundus relaxing drug in functional dyspepsia: effect on symptoms and gastric sensory motor function (abstr)","volume":"116","author":"Tack J","year":"1999","journal-title":"Gastroenterology"},{"key":"e_1_2_5_56_2","first-page":"A70","article-title":"A placebo\u2010controlled trial of the 5\u2010HT1A agonist R\u2010137696 on symptoms, visceral hypersensitivity and on impaired accommodation in functional dyspepsia (abstr)","volume":"126","author":"Tack J","year":"2004","journal-title":"Gastroenterology"},{"key":"e_1_2_5_57_2","first-page":"A437","article-title":"The influence of the 5HT\u20101A agonist R\u2010137696 on proximal stomach function in healthy volunteers (abstr)","volume":"126","author":"Boeckxstaens G","year":"2004","journal-title":"Gastroenterology"},{"key":"e_1_2_5_58_2","doi-asserted-by":"publisher","DOI":"10.1016\/0165-1838(92)90128-4"},{"key":"e_1_2_5_59_2","first-page":"404","article-title":"Pharmacological characterization of alpha adrenoreceptors in the rat gastric fundus","volume":"231","author":"Verplanken P","year":"1984","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_60_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(99)70179-4"},{"key":"e_1_2_5_61_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2004.07.005"},{"key":"e_1_2_5_62_2","first-page":"387","article-title":"Efficacy and tolerability of itopride hydrochloride in patients with non\u2010ulcer dyspepsia","volume":"101","author":"Shenoy KT","year":"2003","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_5_63_2","first-page":"735","article-title":"Randomized, double\u2010blind, comparative study to evaluate the efficacy and safety of ganaton (itopride hydrochloride) and mosapride citrate in the management of functional dyspepsia","volume":"102","author":"Amarapurkar DN","year":"2003","journal-title":"J Indian Med Assoc"},{"key":"e_1_2_5_64_2","first-page":"626","article-title":"Comparative evaluation of the efficacy and tolerability of itopride hydrochloride and domperidone in patients with non\u2010ulcer dyspepsia","volume":"52","author":"Sawant P","year":"2004","journal-title":"J Assoc Physicians India"},{"key":"e_1_2_5_65_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa052639"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2982.2006.00863.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2982.2006.00863.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,10]],"date-time":"2023-10-10T21:07:42Z","timestamp":1696972062000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2982.2006.00863.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,12,7]]},"references-count":64,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1365-2982.2006.00863.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2982.2006.00863.x","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,12,7]]}}}