{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T23:12:37Z","timestamp":1789859557582,"version":"4.0.1"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2006,12,13]],"date-time":"2006-12-13T00:00:00Z","timestamp":1165968000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2007,1]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract\u2002<\/jats:bold>\n                    ATI\u20107505, an investigational 5\u2010HT\n                    <jats:sub>4<\/jats:sub>\n                    receptor agonist, was designed to have similar activity as cisapride without the cardiac adverse effects, i.e. without QT prolongation. In addition, ATI\u20107505 is not metabolized by CYP450. The aim of the study was to assess the effect of ATI\u20107505 on gastrointestinal (GI) and colonic transit in healthy humans. A randomized, parallel\u2010group, double\u2010blind, placebo\u2010controlled study evaluated effects of 9\u2010day treatment with ATI\u20107505 (3, 10 or 20\u2003mg t.i.d.) on scintigraphic GI and colonic transit in healthy volunteers (12 per group). Primary endpoints were gastric\u2010emptying (GE) T\n                    <jats:sub>1\/2<\/jats:sub>\n                    , colonic geometric centre (GC) at 24\u2003h and ascending colon (AC) emptying T\n                    <jats:sub>1\/2<\/jats:sub>\n                    . Daily stool diaries were kept. Analysis of covariance assessed overall treatment group differences, followed by post hoc unadjusted pairwise comparisons. There were borderline overall treatment effects (decrease) on GE T\n                    <jats:sub>1\/2<\/jats:sub>\n                    (P\u2003=\u20030.154); the 20\u2003mg t.i.d. of ATI\u20107505\u2010accelerated GE vs placebo (P\u2003=\u20030.038). ATI\u20107505 increased colonic transit (GC24, P\u2003=\u20030.031) with fastest transit at 10\u2003mg t.i.d. vs placebo (P\u2003=\u20030.065). ATI\u20107505 accelerated AC emptying T\n                    <jats:sub>1\/2<\/jats:sub>\n                    (overall P\u2003=\u20030.075) with 10\u2003mg dose vs placebo (P\u2003=\u20030.042). There was looser stool (Bristol stool form scale, overall P\u2003=\u20030.056) with the 10 and 20\u2003mg t.i.d. doses. No safety issues were identified. ATI\u20107505 accelerates overall colonic transit and tends to accelerate GE and AC emptying and loosen stool consistency.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00865.x","type":"journal-article","created":{"date-parts":[[2006,12,14]],"date-time":"2006-12-14T01:39:36Z","timestamp":1166060376000},"page":"30-38","source":"Crossref","is-referenced-by-count":87,"title":["Pharmacodynamic effects of a novel prokinetic 5\u2010HT\n                    <sub>4<\/sub>\n                    receptor agonist, ATI\u20107505, in humans"],"prefix":"10.1111","volume":"19","author":[{"given":"M.","family":"Camilleri","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. 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