{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:03:46Z","timestamp":1773803026404,"version":"3.50.1"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T00:00:00Z","timestamp":1168473600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2007,2]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold>The objective of this study was to investigate the effects of cyclooxygenase\u20102 (COX\u20102) inhibitor (celecoxib) on delayed gastric emptying and gastric dysrhythmia induced by glucagon. The study was performed in six healthy female dogs implanted with four pairs of gastric serosal electrodes, and a duodenal fistula for the assessment of gastric emptying. Each dog was studied in three randomized sessions: control, glucagon and COX\u20102 inhibitor (celecoxib). Gastric emptying was assessed every 15\u2003min via a duodenal cannula by calculating the amount of collected phenol red which mixed with the test meal and gastric slow waves were recorded at the same time. We found that: (i) glucagon significantly and substantially decreased gastric emptying of liquids (P\u2003&lt;\u20030.001,<jats:sc>anova<\/jats:sc>), increased blood glucose (BG) levels, and induced gastric dysrhythmias. The delayed gastric emptying was correlated with the BG level (R\u2003=\u2003\u22120.77, P\u2003&lt;\u20030.001) and (ii) celecoxib improved glucagon\u2010induced delayed gastric emptying at 30, 45, 60 and 75\u2003min after feeding. Celecoxib did not blocked dysrhythmic action of glucagon (P\u2003&gt;\u20030.05,<jats:sc>anova<\/jats:sc>). In conclusion, glucagon induces delayed gastric emptying partially via COX\u20102\u2010derived prostaglandins. However, COX\u20102\u2010derived prostaglandins are not involved in glucagon\u2010evoked gastric dysrhythemia. Selective COX\u20102 inhibitors may provide a possible therapeutic option for diabetic gastroparesis.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00887.x","type":"journal-article","created":{"date-parts":[[2007,1,11]],"date-time":"2007-01-11T09:42:27Z","timestamp":1168508547000},"page":"144-151","source":"Crossref","is-referenced-by-count":14,"title":["Effects of cyclooxygenase\u20102 inhibitor on glucagon\u2010induced delayed gastric emptying and gastric dysrhythmia in dogs"],"prefix":"10.1111","volume":"19","author":[{"given":"J.","family":"Xu","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J. D. Z.","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2007,1,11]]},"reference":[{"key":"e_1_2_5_2_2","doi-asserted-by":"publisher","DOI":"10.1055\/s-2003-40467"},{"key":"e_1_2_5_3_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI26295"},{"key":"e_1_2_5_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70080-5"},{"key":"e_1_2_5_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90445-X"},{"key":"e_1_2_5_6_2","doi-asserted-by":"publisher","DOI":"10.1097\/00042737-199603000-00005"},{"key":"e_1_2_5_7_2","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.072868"},{"key":"e_1_2_5_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0090-6980(94)90072-8"},{"key":"e_1_2_5_9_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(87)90975-9"},{"key":"e_1_2_5_10_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00619.x"},{"key":"e_1_2_5_11_2","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.pharmtox.38.1.97"},{"key":"e_1_2_5_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4266(06)72590-2"},{"key":"e_1_2_5_13_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33065"},{"key":"e_1_2_5_14_2","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-132-2-200001180-00008"},{"key":"e_1_2_5_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90382-8"},{"key":"e_1_2_5_16_2","first-page":"92","article-title":"Effect of glucagons on gastric emptying and on postprandial gastrin and insulin release in man","volume":"21","author":"Jonderko G","year":"1989","journal-title":"Mater Med Pol"},{"key":"e_1_2_5_17_2","doi-asserted-by":"publisher","DOI":"10.1159\/000077390"},{"key":"e_1_2_5_18_2","doi-asserted-by":"publisher","DOI":"10.1080\/003655201750422648"},{"key":"e_1_2_5_19_2","first-page":"1475","article-title":"Effects of glucagons on gastric motility examined by the acetaminophen absorption method and the endoscopic procedure","volume":"35","author":"Kawamoto H","year":"1985","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_5_20_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018852011857"},{"key":"e_1_2_5_21_2","first-page":"G826","article-title":"Acceleration of gastric emptying with electrical stimulation in a canine model of gastroparesis","volume":"262","author":"Bellahsene BE","year":"1992","journal-title":"Am J Physiol"},{"key":"e_1_2_5_22_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022532515172"},{"key":"e_1_2_5_23_2","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/S0022-3565(24)29580-X","article-title":"Pharmacokinetics of celecoxib after oral administration in dogs and humans: effect of food and site of absorption","volume":"297","author":"Paulson SK","year":"2001","journal-title":"J Pharmacol Exp Ther"},{"key":"e_1_2_5_24_2","first-page":"45","volume-title":"The Electrogastrography: Principles and Clinical Applications","author":"Chen JDZ","year":"1994"},{"key":"e_1_2_5_25_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1013726223531"},{"key":"e_1_2_5_26_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0889-8553(05)70035-2"},{"key":"e_1_2_5_27_2","first-page":"47","article-title":"Glyceamic control and gastric emptying","volume":"17","author":"Spallone V.","year":"2004","journal-title":"Diabetes Nutr Metab"},{"key":"e_1_2_5_28_2","doi-asserted-by":"publisher","DOI":"10.1096\/fj.03-0645rev"},{"key":"e_1_2_5_29_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI200215318"},{"key":"e_1_2_5_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90412-X"},{"key":"e_1_2_5_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0016-5085(97)70080-5"},{"key":"e_1_2_5_32_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00168.2002"},{"key":"e_1_2_5_33_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0003-4266(06)72590-2"},{"key":"e_1_2_5_34_2","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2007.S190"},{"key":"e_1_2_5_35_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2004.00547.x"},{"key":"e_1_2_5_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11938-006-0017-4"},{"key":"e_1_2_5_37_2","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(82)90572-6"},{"key":"e_1_2_5_38_2","first-page":"149","article-title":"Identification of glucagon binding sites on smooth muscle tissue of dog intestine. Quantification by means of ultrastructural autoradiography","volume":"172","author":"Santamaria L","year":"1991","journal-title":"Anat Anz"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2982.2006.00887.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2982.2006.00887.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,1,12]],"date-time":"2025-01-12T22:20:39Z","timestamp":1736720439000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2982.2006.00887.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,11]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2007,2]]}},"alternative-id":["10.1111\/j.1365-2982.2006.00887.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2982.2006.00887.x","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,1,11]]}}}