{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,3]],"date-time":"2025-11-03T13:22:09Z","timestamp":1762176129454},"reference-count":38,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T00:00:00Z","timestamp":1174867200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> In somatic models of central sensitisation (CS) allodynia develops following changes to somatic A\u2010\u03b2 fibres, allowing these afferents which normally only process innocuous sensations to encode pain. The aim of this study was to determine whether somatic allodynia induced by visceral sensitisation occurs via N\u2010Methyl\u2010D\u2010Aspartate (NMDA) receptor mediated changes to the neurophysiological characteristics of somatic A\u2010\u03b2 fibres. Twelve healthy subjects had oesophageal, chest wall and foot pain thresholds (PT) to electrical stimulation measured, and chest wall evoked potentials (CEP) recorded before and 30 minutes after distal oesophageal acidification on 2 separate visits. Intravenous ketamine (an NMDA receptor antagonist) or saline was given 30 minutes post acid with repeated oesophageal and chest wall PT measurements and CEP recordings. Distal oesophageal acidification reduced PT to electrical stimulation on the anterior chest wall (37\u2003\u00b1\u200310mA v 29\u2003\u00b1\u20037mA p\u2003=\u20030.01) and proximal oesophagus (46\u2003\u00b1\u200310mA v 33\u2003\u00b1\u200311mA p\u2003=\u20030.001) but not the foot (37\u2003\u00b1\u200325mA v 39\u2003\u00b1\u200323mA p\u2003=\u20030.12). The induction of chest wall somatic allodynia was accompanied by a reduction in the latency of the P1 (36\u2003\u00b1\u20033ms to 30\u2003\u00b1\u20034ms p\u2003=\u20030.016) and P2 (87\u2003\u00b1\u20037 ms to v 76\u2003\u00b1\u20037ms p\u2003=\u20030.049) components of the CEP. NMDA receptor antagonism reversed both visceral and somatic pain hypersensitivity but did not affect CEP latencies. These data provide objective neurophysiological evidence that CS contributes to the development of somatic allodynia following visceral sensitisation.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2006.00890.x","type":"journal-article","created":{"date-parts":[[2007,3,26]],"date-time":"2007-03-26T13:35:09Z","timestamp":1174916109000},"page":"270-278","source":"Crossref","is-referenced-by-count":32,"title":["Exploring the neurophysiological basis of chest wall allodynia induced by experimental oesophageal acidification \u2013 evidence of central sensitization<sup>1<\/sup>"],"prefix":"10.1111","volume":"19","author":[{"given":"R. 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