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It also acts on vagal afferents altering motility and in large amounts induces nausea. Rapid reuptake by a specific transporter (serotonin transporter, SERT) limits its diffusion and actions. Abnormally increased 5\u2010HT is found in a range of gastrointestinal disorders including chemotherapy\u2010induced nausea and vomiting, carcinoid syndrome, coeliac disease, inflammatory bowel disease and irritable bowel syndrome (IBS) with diarrhoea (IBS\u2010D), especially that developing following enteric infection. Impaired SERT has been described in IBS\u2010D and might account for some of the increase in mucosal 5\u2010HT availability. 5\u2010HT<jats:sub>3<\/jats:sub>receptor antagonists inhibit chemotherapy\u2010induced nausea and diarrhoea associated with both carcinoid syndrome and IBS. While IBS\u2010D is associated with increased 5\u2010HT postprandially, IBS with constipation (IBS\u2010C) is associated with impaired 5\u2010HT response and responds to 5\u2010HT<jats:sub>4<\/jats:sub>agonists such as Prucalopride and 5\u2010HT<jats:sub>4<\/jats:sub>partial agonists such as Tegaserod.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2007.00965.x","type":"journal-article","created":{"date-parts":[[2007,7,7]],"date-time":"2007-07-07T00:55:34Z","timestamp":1183769734000},"page":"25-31","source":"Crossref","is-referenced-by-count":141,"title":["Recent advances in understanding the role of serotonin in gastrointestinal motility in functional bowel disorders: alterations in 5\u2010HT signalling and metabolism in human 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