{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T00:05:54Z","timestamp":1790726754827,"version":"4.1.0"},"reference-count":37,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T00:00:00Z","timestamp":1184716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2007,12]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> The water drink test is a good tool to evoke dyspeptic symptoms. To what extent these symptoms are related to altered gastric distribution is not clear. Therefore, we determined gastric volumes after a drink test using SPECT. After a baseline scan 20 healthy volunteers (HV) and 18 patients with functional dyspepsia (FD) underwent a drink test (100\u2003mL\u2003min<jats:sup>\u22121<\/jats:sup>) followed by five scans up to 2\u2003h. Dyspeptic symptoms were scored before every scan. A Wilcoxon signed rank test (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) and a mixed effects model were used for statistical analyses. Fasting volumes were significantly higher in FD compared to HV for total, proximal and distal stomach (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001). Functional dyspeptic patients ingested significantly less water (<jats:italic>P<\/jats:italic>\u2003&lt;\u20030.001) and had an impaired filling of the distal part of the stomach (<jats:italic>P<\/jats:italic>\u2003=\u20030.001) after the drink test. In FD, bloating (prox. 80%, dist. 56%), pain (prox. 87%, dist. 62%) and fullness (prox. 80%, dist. 59%) were determined more by proximal stomach volume rather than distal stomach volume. These data suggest that drinking capacity is mainly determined by antral volume, with a reduced antral filling in FD compared to HV. The persisting symptoms of bloating, pain and fullness in FD are predominantly associated with proximal stomach volume.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2007.00971.x","type":"journal-article","created":{"date-parts":[[2007,7,18]],"date-time":"2007-07-18T11:57:05Z","timestamp":1184759825000},"page":"968-976","source":"Crossref","is-referenced-by-count":26,"title":["Impaired drinking capacity in patients with functional dyspepsia: intragastric distribution and distal stomach volume"],"prefix":"10.1111","volume":"19","author":[{"given":"B. D.","family":"Van Den Elzen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R. 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