{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T18:05:09Z","timestamp":1791309909824,"version":"4.3.1"},"reference-count":32,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2007,12,21]],"date-time":"2007-12-21T00:00:00Z","timestamp":1198195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2008,4]]},"abstract":"<jats:p><jats:bold>Abstract\u2002<\/jats:bold> Autonomic nervous system dysfunction has been implicated in the pathophysiology of irritable bowel syndrome (IBS). This study characterized the autonomic response to rectal distension in IBS using baroreceptor sensitivity (BRS), a measure of autonomic function. Rectal bag pressure, discomfort, pain, ECG, blood pressure and BRS were continuously measured before, during and after rectal distension in 98 healthy volunteers (34\u2003\u00b1\u200312 years old, 52 females) and 39 IBS patients (39\u2003\u00b1\u200311 years old, 35 females). In comparison with the healthy volunteers, IBS patients experienced significantly more discomfort (69\u2003\u00b1\u20032.2% vs 56\u2003\u00b1\u20033.6%; P\u2003&lt;\u20030.05), but not pain (9\u2003\u00b1\u20031.4% vs 6\u2003\u00b1\u20032.4%; ns) with rectal distension despite similar distension pressures (51\u2003\u00b1\u20031.4 vs 54\u2003\u00b1\u20032.4\u2003mmHg; ns) and volumes (394\u2003\u00b1\u200310.9 vs 398\u2003\u00b1\u200321.5\u2003mL; ns). With rectal distension, heart rate increased in both healthy volunteers (66\u2003\u00b1\u20031 to 71\u2003\u00b1\u20031 bpm; P\u2003&lt;\u20030.05) and IBS patients (66\u2003\u00b1\u20032 to 74\u2003\u00b1\u20033 bpm; P\u2003&lt;\u20030.05). Systolic blood pressure also increased in both healthy volunteers (121\u2003\u00b1\u20032 to 143\u2003\u00b1\u20032\u2003mmHg; P\u2003&lt;\u20030.05) and patients (126\u2003\u00b1\u20033 to 153\u2003\u00b1\u20034\u2003mmHg (P\u2003&lt;\u20030.05) as did diastolic blood pressure, 66\u2003\u00b1\u20032 to 80\u2003\u00b1\u20032\u2003mmHg (P\u2003&lt;\u20030.05), compared with 68\u2003\u00b1\u20033 to 84\u2003\u00b1\u20033\u2003mmHg (P\u2003&lt;\u20030.05) in IBS patients. The systolic blood pressure increase observed in IBS patients was greater than that seen in healthy volunteers and remained elevated in the post distension period (139\u2003\u00b1\u20033\u2003mmHg vs 129\u2003\u00b1\u20032\u2003mmHg; P\u2003&lt;\u20030.05). IBS patients had lower BRS (7.85\u2003\u00b1\u20030.4\u2003ms mmHg<jats:sup>\u22121<\/jats:sup>) compared with healthy volunteers (9.4\u2003\u00b1\u20030.3; P\u2003&lt;\u20030.05) at rest and throughout rectal distension. Greater systolic blood pressure response to rectal distension and associated diminished BRS suggests a compromise of the autonomic nervous system in IBS patients.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2007.01042.x","type":"journal-article","created":{"date-parts":[[2008,3,27]],"date-time":"2008-03-27T05:48:04Z","timestamp":1206596884000},"page":"336-342","source":"Crossref","is-referenced-by-count":50,"title":["Vagal dysfunction in irritable bowel syndrome assessed by rectal distension and baroreceptor sensitivity"],"prefix":"10.1111","volume":"20","author":[{"given":"R.","family":"Spaziani","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Bayati","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Redmond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Bajaj","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Bienenstock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S. M.","family":"Collins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. V.","family":"Kamath","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2007,12,21]]},"reference":[{"key":"e_1_2_7_2_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_7_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.37095"},{"key":"e_1_2_7_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.gtc.2005.02.010"},{"key":"e_1_2_7_5_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.14.2.125"},{"key":"e_1_2_7_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90267-8"},{"key":"e_1_2_7_7_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.41.4.505"},{"key":"e_1_2_7_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(90)90332-U"},{"key":"e_1_2_7_9_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01677.x"},{"key":"e_1_2_7_10_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90434-4"},{"key":"e_1_2_7_11_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF02065555"},{"key":"e_1_2_7_12_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.2002.33601"},{"key":"e_1_2_7_13_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.48.1.20"},{"key":"e_1_2_7_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01009.x"},{"key":"e_1_2_7_15_2","doi-asserted-by":"publisher","DOI":"10.1097\/00000441-192812000-00006"},{"key":"e_1_2_7_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90753-6"},{"key":"e_1_2_7_17_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00861.x"},{"key":"e_1_2_7_18_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016424007454"},{"key":"e_1_2_7_19_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02318.x"},{"key":"e_1_2_7_20_2","volume-title":"Rome II. The Functional Gastrointestinal Disorders. Diagnosis, Pathophysiology andTreatment: A Multinational Consensus","author":"Drossman DA","year":"2000"},{"key":"e_1_2_7_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-006-0154-x"},{"key":"e_1_2_7_22_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.HYP.37.3.911"},{"key":"e_1_2_7_23_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000135362.35665.49"},{"key":"e_1_2_7_24_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00607.2004"},{"key":"e_1_2_7_25_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.49.5.706"},{"key":"e_1_2_7_26_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.2975"},{"key":"e_1_2_7_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(89)90627-6"},{"key":"e_1_2_7_28_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2003.11.055"},{"key":"e_1_2_7_29_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.11.039"},{"key":"e_1_2_7_30_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI30555"},{"key":"e_1_2_7_31_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.033"},{"key":"e_1_2_7_32_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2006.08.016"},{"issue":"4","key":"e_1_2_7_33_2","first-page":"A50","article-title":"The vagus nerve is involved in constitutive downregulation of acute and chronic intestinal inflammation through the alpha7 nicotinic receptor pathway","volume":"132","author":"Van der kleij HP","year":"2007","journal-title":"Gastoenterology"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2982.2007.01042.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2982.2007.01042.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,11]],"date-time":"2023-10-11T01:31:14Z","timestamp":1696987874000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2982.2007.01042.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,12,21]]},"references-count":32,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4]]}},"alternative-id":["10.1111\/j.1365-2982.2007.01042.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2982.2007.01042.x","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2007,12,21]]}}}