{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,5]],"date-time":"2026-11-05T11:28:33Z","timestamp":1793878113605,"version":"4.7.0"},"reference-count":52,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T00:00:00Z","timestamp":1203379200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2008,6]]},"abstract":"<jats:p>\n                    <jats:bold>Abstract\u2002<\/jats:bold>\n                    Glucagon\u2010like peptide\u20101 (GLP\u20101) is released after food intake to act as an incretin. GLP\u20101 also inhibits gastric emptying and increases satiety. In rats, GLP\u20101 inhibits small bowel motility. Our aim was to study the effects of GLP\u20101 on gastrointestinal motility in healthy subjects and patients with irritable bowel syndrome (IBS). Antro\u2010duodeno\u2010jejunal manometry was carried out during a 4\u2010h control period with saline, followed by a 4\u2010h period with intravenous GLP\u20101 (healthy: 0.7 and 1.2\u2003pmol\u2003kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2003min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200316); IBS, 1.2 and 2.5\u2003pmol\u2003kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2003min\n                    <jats:sup>\u22121<\/jats:sup>\n                    (\n                    <jats:italic>n<\/jats:italic>\n                    \u2003=\u200314). Plasma was analysed for GLP\u20101 and gut hormones, and gut tissue expression of GLP\u20101 receptor was studied. In healthy subjects, GLP\u20101 0.7\u2003pmol\u2003kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2003min\n                    <jats:sup>\u22121<\/jats:sup>\n                    reduced the migrating motor complexes (MMCs) from a median of 2 (range 2\u20133) to 0.5 (0\u20132), and motility index from 4.9\u2003\u00b1\u20030.1 to 4.3\u2003\u00b1\u20030.3\u2003ln \u2211(mmHg*s\u2003min\n                    <jats:sup>\u22121<\/jats:sup>\n                    ) in jejunum, while GLP\u20101 1.2\u2003pmol\u2003kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2003min\n                    <jats:sup>\u22121<\/jats:sup>\n                    diminshed MMCs from 2 (2\u20133) to 1.5 (1\u20132.5), and motility index from 5.2\u2003\u00b1\u20030.2 to 4.4\u2003\u00b1\u20030.2. In IBS patients, GLP\u20101 1.2\u2003pmol\u2003kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2003min\n                    <jats:sup>\u22121<\/jats:sup>\n                    reduced the MMCs from 2.5 (2\u20133.5) to 1 (0\u20131.5) without affecting motility index. At 2.5\u2003pmol\u2003kg\n                    <jats:sup>\u22121<\/jats:sup>\n                    \u2003min\n                    <jats:sup>\u22121<\/jats:sup>\n                    GLP\u20101 decreased MMCs from 2 (1.5\u20133) to 1 (0.5\u20131.5), and motility index from 5.2\u2003\u00b1\u20030.2 to 4.0\u2003\u00b1\u20030.5. Motility responses to GLP\u20101 were similar in antrum and duodenum. Presence of the GLP\u20101 receptor in the gut was verified by reverse transcriptase PCR. In conclusion, the gut peptide GLP\u20101 decreases motility in the antro\u2010duodeno\u2010jejunal region and inhibits the MMC in healthy subjects and IBS patients.\n                  <\/jats:p>","DOI":"10.1111\/j.1365-2982.2007.01079.x","type":"journal-article","created":{"date-parts":[[2008,2,19]],"date-time":"2008-02-19T09:36:02Z","timestamp":1203413762000},"page":"649-659","source":"Crossref","is-referenced-by-count":142,"title":["GLP\u20101 suppresses gastrointestinal motility and inhibits the migrating motor complex in healthy subjects and patients with irritable bowel syndrome"],"prefix":"10.1111","volume":"20","author":[{"given":"P. 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