{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,10,15]],"date-time":"2023-10-15T04:15:18Z","timestamp":1697343318184},"reference-count":35,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T00:00:00Z","timestamp":1309392000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2011,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> To investigate the association between the gastric emptying rate and the presence of erosive esophagitis in duodenal ulcer (DU) patients among a population with high prevalence of <jats:italic>Helicobacter pylori<\/jats:italic> infection.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Cross\u2010sectional survey was performed in a cohort of 60 male patients with either active or healed DU, with or without the presence of erosive esophagitis. Clinical and social\u2010demographic data, blood level of fasting gastrin, pepsinogen I &amp; I\/II ratio, and scintigraphic measurement of half emptying time (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>) of the solid phase gastric emptying were evaluated.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> Patients with active DU and erosive esophagitis tended to have higher plasma level of fasting gastrin than those without erosive esophagitis (75.11\u2003\u00b1\u200313.74 <jats:italic>vs<\/jats:italic> 45.81\u2003\u00b1\u20035.06\u2003pg\u2003mL<jats:sup>\u22121<\/jats:sup>, <jats:italic>P<\/jats:italic> = 0.059). In the absence of <jats:italic>H. pylori<\/jats:italic> infection, patients with healed DU and erosive esophagitis had a trend to have longer half\u2010emptying time (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>: 96.5\u2003\u00b1\u20036.4 <jats:italic>vs<\/jats:italic> 69.1\u2003\u00b1\u200311.3\u2003min, <jats:italic>P<\/jats:italic>\u2003=\u20030.0572) than those without erosive esophagitis, and statistically significant longer after excluding those diagnosed with hiatal hernia (<jats:italic>t<\/jats:italic><jats:sub>1\/2<\/jats:sub>: 100.8\u2003\u00b1\u20037.9\u2003min <jats:italic>vs<\/jats:italic> 69.1\u2003\u00b1\u200311.3\u2003min, <jats:italic>P<\/jats:italic>\u2003&lt;\u20030.05) from the former group. Among the healed DU patients, those with negative <jats:italic>H. pylori<\/jats:italic> infection, hiatal hernia and overweight (body mass index \u226524) had significantly increased risk of severe esophagitis.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> Presence of erosive esophagitis in a subset of Taiwanese patients with healed DU and negative <jats:italic>H. pylori<\/jats:italic> status was associated with slower solid phase gastric emptying.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2011.01740.x","type":"journal-article","created":{"date-parts":[[2011,6,30]],"date-time":"2011-06-30T15:32:15Z","timestamp":1309447935000},"page":"840-845","source":"Crossref","is-referenced-by-count":1,"title":["Duodenal ulcer disease, gastroduodenal motor function and reflux esophagitis \u2013 a cross\u2010sectional survey in a subset of Taiwanese 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