{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T04:28:38Z","timestamp":1792988918094,"version":"4.5.0"},"reference-count":31,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T00:00:00Z","timestamp":1312156800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Our primary goals were to investigate the effects of two\u2010channel gastric pacing on gastric myoelectrical activity, and energy consumption with the secondary intent to monitor gastric emptying and symptoms in patients with severe diabetic gastroparesis.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Four pairs of temporary pacing wires were inserted on the serosa of the stomach at the time of laparotomy to place the Enterra\u2122 System in 19 patients with severe gastroparesis not responding to standard medical therapies. Two of the pairs were for electrical stimulation and the other two for recording. Five days after surgery the optimal pacing parameters for the entrainment of gastric slow waves in each patient were identified by serosal recordings. Two\u2010channel gastric pacing was then initiated for 6\u2003weeks using a newly developed external multi\u2010channel pulse generator. Electrogastrogram (EGG), Total Symptom Score (TSS), and a 4\u2010h gastric emptying test were assessed at baseline and after 6\u2003weeks of active gastric pacing. Enterra\u2122 device was turned OFF during the duration of this study.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> Two\u2010channel gastric pacing at 1.1 times the intrinsic frequency entrained gastric slow waves and normalized gastric dysrhythmia. After 6\u2003weeks of gastric pacing, tachygastria was decreased from 15\u2003\u00b1\u20033 to 5\u2003\u00b1\u20031% in the fasting state and from 10\u2003\u00b1\u20032 to 5\u2003\u00b1\u20031% postprandially (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05), mean TSS was reduced from 21.3\u2003\u00b1\u20031.1 to 7.0\u2003\u00b1\u20031.5 (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.05) and mean 4\u2010h gastric retention improved from 42 to 28% (<jats:italic>P\u2003<\/jats:italic>=\u20030.05).<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> Two\u2010channel gastric pacing is a novel treatment approach which is able to normalize and enhance gastric slow wave activity as well as accelerate gastric emptying in patients with diabetic gastroparesis with a goal safety profile.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2011.01754.x","type":"journal-article","created":{"date-parts":[[2011,8,2]],"date-time":"2011-08-02T02:23:44Z","timestamp":1312251824000},"page":"912","source":"Crossref","is-referenced-by-count":37,"title":["Two\u2010channel gastric pacing in patients with diabetic gastroparesis"],"prefix":"10.1111","volume":"23","author":[{"given":"Zhiyue","family":"Lin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Sarosiek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jameson","family":"Forster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Ross","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiande D. 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