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Delayed gastric emptying and hypersensitivity to gastric distension (GD) contribute importantly to the pathophysiology of FD.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> In the present study, we determined the influence of pentagastrin\u2010stimulated endogenous gastric acid on gastric emptying and GD\u2010induced pain responses using rat model systems. Moreover, we evaluated the effects of famotidine and mosapride on changes in gastric emptying and the GD\u2010induced pain response to gastric acid hypersecretion. Gastric emptying was measured by excretion of glass beads that had been intragastrically administered with a liquid nutrient, and gastric pain response was evaluated by observing whether a GD\u2010induced increase in mean blood pressure occurred.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> Pentagastrin (2\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>, s.c.) which markedly and continuously stimulated gastric acid secretion, significantly delayed and enhanced respectively, gastric emptying and pain compared with saline\u2010injected groups. Oral famotidine (0.1\u20133\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) and mosapride (0.3\u20133\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) administration in a dose\u2010dependent manner accelerated the delay of gastric emptying. Furthermore, famotidine (0.3\u20133\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) significantly alleviated the aggravation of the GD\u2010induced pain response, but mosapride (10\u2003mg\u2003kg<jats:sup>\u22121<\/jats:sup>) did not.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> We established rat models to evaluate the effect of gastric acid hypersecretion on gastric emptying and the GD\u2010induced pain response. In these models, acid hypersecretion delayed gastric emptying and aggravated the pain response. Furthermore, we showed that famotidine ameliorated both delayed gastric emptying and gastric hypersensitivity, whereas mosapride only improved delayed gastric emptying.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2011.01809.x","type":"journal-article","created":{"date-parts":[[2011,11,9]],"date-time":"2011-11-09T01:43:38Z","timestamp":1320803018000},"page":"147","source":"Crossref","is-referenced-by-count":9,"title":["Influence of gastric acid on gastric emptying and gastric distension\u2010induced pain response in rats \u2013 effects of famotidine and 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