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The aim of investigation is to provide clinically relevant measurements of gastrointestinal structure and function that explain the cause of symptoms, identify pathology, and guide effective management. Current practice rarely meets these ideals.<\/jats:p><jats:p><jats:bold>Purpose\u2002<\/jats:bold> This review considers recent advances in technology such as high\u2010resolution manometry (HRM) with esophageal pressure topography (EPT), HRM with impedance, high frequency ultrasound, and endoscopic functional luminal impedance planimetry (Endo\u2010FLIP) that provide new opportunities to identify the pathophysiologic basis of esophageal symptoms and disease. As experience with these new devices increases researchers are developing new methodologies that maximize their utility in clinical practice. For example, application of HRM to assess motility and function during and after a test meal can identify the causes of swallowing problems, reflux and other postprandial symptoms and intra\u2010operative application of Endo\u2010FLIP may help surgeons perform antireflux surgery. These examples illustrate the potential of physiologic measurement to direct rational and effective clinical management for individual patients.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2011.01835.x","type":"journal-article","created":{"date-parts":[[2012,1,17]],"date-time":"2012-01-17T05:19:49Z","timestamp":1326777589000},"page":"48-56","source":"Crossref","is-referenced-by-count":20,"title":["Future directions in esophageal motility and function \u2013 new technology and methodology"],"prefix":"10.1111","volume":"24","author":[{"given":"M.","family":"Fox","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Sweis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,16]]},"reference":[{"key":"e_1_2_7_2_2","first-page":"780","article-title":"Value of physiologic assessment of foregut symptoms in a surgical 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