{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:30:03Z","timestamp":1790544603189,"version":"4.1.0"},"reference-count":83,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T00:00:00Z","timestamp":1326931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Patients with irritable bowel syndrome (IBS) often present with disturbances of bowel habits (diarrhea, constipation) and abdominal pain\/discomfort that are modulated by the autonomic nerve system (ANS). In this narrative review, we analyzed studies that measured ANS functioning in IBS by means of heart rate variability (HRV).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> The PUBMED was searched with the keywords \u2018irritable bowel syndrome\u2019 AND (\u2018heart rate variability\u2019 OR \u2018autonomic function\u2019). We included only papers that used \u2018traditional\u2019 HRV indices and diagnosed IBS based on Manning or Rome criteria. Studies were sub\u2010grouped according to methodological features of HRV analysis (24\u2010h monitoring, short\u2010term laboratory records, records during sleep).<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> Most studies reported no difference in HRV when the IBS population was compared to healthy controls. Dividing the IBS sample into subgroups \u2013 according to their predominant bowel symptoms, the severity of clinical course, the presence of depressive symptoms, or a history of abuse in the past \u2013 revealed changes in autonomic functioning.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> Patients with IBS appear to experience symptoms that may be the result of changes in ANS functioning. HRV measures in clinical routine may allow assessing these changes, but further studies performed in a standardized fashion should improve the validity of HRV measures for clinical research first.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2011.01866.x","type":"journal-article","created":{"date-parts":[[2012,1,19]],"date-time":"2012-01-19T08:19:31Z","timestamp":1326961171000},"page":"206-216","source":"Crossref","is-referenced-by-count":91,"title":["Heart rate variability in the irritable bowel syndrome: a review of the literature"],"prefix":"10.1111","volume":"24","author":[{"given":"N.","family":"Mazurak","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Seredyuk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Sauer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Teufel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Enck","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,1,19]]},"reference":[{"key":"e_1_2_8_2_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2005.02671.x"},{"key":"e_1_2_8_3_2","doi-asserted-by":"publisher","DOI":"10.1053\/gast.1997.v112.agast972120"},{"key":"e_1_2_8_4_2","first-page":"S17","article-title":"Impairment in work productivity and health\u2010related quality of life in patients with IBS","volume":"11","author":"Dean BB","year":"2005","journal-title":"Am J Manag Care"},{"key":"e_1_2_8_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2004.02183.x"},{"key":"e_1_2_8_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90738-6"},{"key":"e_1_2_8_7_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2036.2002.01305.x"},{"key":"e_1_2_8_8_2","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.2.6138.653"},{"key":"e_1_2_8_9_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.45.2008.ii1"},{"key":"e_1_2_8_10_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.11.061"},{"key":"e_1_2_8_11_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.01437.x"},{"key":"e_1_2_8_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04074.x"},{"key":"e_1_2_8_13_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03893.x"},{"key":"e_1_2_8_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03804.x"},{"key":"e_1_2_8_15_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(92)90310-U"},{"key":"e_1_2_8_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90267-8"},{"key":"e_1_2_8_17_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365527809181914"},{"key":"e_1_2_8_18_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2006.00654.x"},{"key":"e_1_2_8_19_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.15.3591"},{"key":"e_1_2_8_20_2","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v13.i25.3405"},{"key":"e_1_2_8_21_2","doi-asserted-by":"publisher","DOI":"10.1159\/000050682"},{"key":"e_1_2_8_22_2","doi-asserted-by":"publisher","DOI":"10.1024\/1661-8157\/a000087"},{"key":"e_1_2_8_23_2","first-page":"19","article-title":"Pathogenesis and management of irritable bowel syndrome","volume":"30","author":"Mathew P","year":"2009","journal-title":"Trop Gastroenterol"},{"key":"e_1_2_8_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(95)90439-5"},{"key":"e_1_2_8_25_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01824303"},{"key":"e_1_2_8_26_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2168.1999.00994.x"},{"key":"e_1_2_8_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-1838(97)00043-X"},{"key":"e_1_2_8_28_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02009.x"},{"key":"e_1_2_8_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.CIR.93.5.1043"},{"key":"e_1_2_8_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90795-8"},{"key":"e_1_2_8_31_2","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9149(87)90601-1"},{"key":"e_1_2_8_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-0736(88)90055-6"},{"key":"e_1_2_8_33_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529309096046"},{"key":"e_1_2_8_34_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(94)90753-6"},{"key":"e_1_2_8_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(87)91792-2"},{"key":"e_1_2_8_36_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF01540409"},{"key":"e_1_2_8_37_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018848122993"},{"key":"e_1_2_8_38_2","doi-asserted-by":"publisher","DOI":"10.1002\/erv.1081"},{"key":"e_1_2_8_39_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-006-9305-z"},{"key":"e_1_2_8_40_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600965749"},{"key":"e_1_2_8_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2006.00877.x"},{"key":"e_1_2_8_42_2","doi-asserted-by":"publisher","DOI":"10.1097\/00006842-200109000-00014"},{"key":"e_1_2_8_43_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.02318.x"},{"key":"e_1_2_8_44_2","doi-asserted-by":"publisher","DOI":"10.1023\/B:DDAS.0000037820.54069.6c"},{"key":"e_1_2_8_45_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.psyneuen.2009.10.004"},{"key":"e_1_2_8_46_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1021904216312"},{"key":"e_1_2_8_47_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1018871617483"},{"key":"e_1_2_8_48_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365529850171800"},{"key":"e_1_2_8_49_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.1999.00861.x"},{"key":"e_1_2_8_50_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2001.03526.x"},{"key":"e_1_2_8_51_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2004.058685"},{"issue":"3","key":"e_1_2_8_52_2","first-page":"131","article-title":"Dysfunction of the autonomic nervous system activity is responsible for gastric myoelectric disturbances in the irritable bowel syndrome patients","volume":"58","author":"Mazur M","year":"2007","journal-title":"J Physiol Pharmacol"},{"key":"e_1_2_8_53_2","doi-asserted-by":"publisher","DOI":"10.1177\/1099800410393274"},{"key":"e_1_2_8_54_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2002.07112.x"},{"key":"e_1_2_8_55_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2362.2009.02158.x"},{"key":"e_1_2_8_56_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10286-005-0272-9"},{"key":"e_1_2_8_57_2","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1055\/s-0038-1625405","article-title":"Analysis of heart rate variability to predict patient age in a healthy population","volume":"46","author":"Corino VD","year":"2007","journal-title":"Methods Inf Med"},{"key":"e_1_2_8_58_2","doi-asserted-by":"publisher","DOI":"10.1080\/03091900500442855"},{"key":"e_1_2_8_59_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1542-474X.2008.00231.x"},{"key":"e_1_2_8_60_2","doi-asserted-by":"publisher","DOI":"10.1375\/twin.10.2.364"},{"key":"e_1_2_8_61_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjcard.2003.09.065"},{"key":"e_1_2_8_62_2","doi-asserted-by":"publisher","DOI":"10.1177\/109980040000200203"},{"key":"e_1_2_8_63_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1010671514618"},{"key":"e_1_2_8_64_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.47.6.861"},{"key":"e_1_2_8_65_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.mcg.0000135362.35665.49"},{"key":"e_1_2_8_66_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20030119"},{"key":"e_1_2_8_67_2","doi-asserted-by":"publisher","DOI":"10.1007\/s10620-007-9943-9"},{"key":"e_1_2_8_68_2","first-page":"93","article-title":"Estimation of respiratory frequency from autoregressive spectral analysis of heart period","volume":"32","author":"Thayer JF","year":"1996","journal-title":"Biomed Sci Instrum"},{"key":"e_1_2_8_69_2","volume-title":"The Biological Basis for Mind Body Interactions","author":"Jaenig W","year":"2000"},{"key":"e_1_2_8_70_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2008.03801.x"},{"key":"e_1_2_8_71_2","doi-asserted-by":"publisher","DOI":"10.1016\/0016-5085(88)90006-6"},{"key":"e_1_2_8_72_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1005487821063"},{"key":"e_1_2_8_73_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-3223(94)00130-U"},{"key":"e_1_2_8_74_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1819.2008.01855.x"},{"key":"e_1_2_8_75_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.2003.017962"},{"key":"e_1_2_8_76_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2009.01351.x"},{"key":"e_1_2_8_77_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2009.08.058"},{"key":"e_1_2_8_78_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1016329008921"},{"key":"e_1_2_8_79_2","doi-asserted-by":"publisher","DOI":"10.1088\/0967-3334\/28\/9\/008"},{"key":"e_1_2_8_80_2","doi-asserted-by":"publisher","DOI":"10.1007\/s11517-006-0097-2"},{"key":"e_1_2_8_81_2","doi-asserted-by":"publisher","DOI":"10.1042\/CS20070055"},{"key":"e_1_2_8_82_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijcard.2004.09.013"},{"key":"e_1_2_8_83_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8986.1997.tb02140.x"},{"key":"e_1_2_8_84_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01785.x"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2982.2011.01866.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2982.2011.01866.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T12:19:13Z","timestamp":1698668353000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2982.2011.01866.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,1,19]]},"references-count":83,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2012,3]]}},"alternative-id":["10.1111\/j.1365-2982.2011.01866.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2982.2011.01866.x","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,1,19]]}}}