{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:00:54Z","timestamp":1791489654866,"version":"4.3.4"},"reference-count":31,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,4]],"date-time":"2012-03-04T00:00:00Z","timestamp":1330819200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>Improvement in subjective symptoms has been reported in functional dyspepsia (FD) patients administered with acotiamide. Improvement was confirmed in meal\u2010related symptoms, such as postprandial fullness, upper abdominal bloating, and early satiety. We examined the mechanism underlying the effects of acotiamide on gastric accommodation reflex (GAR) and gastroduodenal motility in FD patients.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Thirty\u2010four FD patients (mean age, 40.4\u2003years) were examined ultrasonographically before and after 14\u201318\u2003days of acotiamide (100\u2003mg t.i.d.) or placebo administration. To assess GAR, expansion rate in cross\u2010sectional area of the proximal stomach was measured after every 100\u2010mL ingestion, using a straw, of up to 400\u2003mL of a liquid meal (consomm\u00e9 soup, 13.1\u2003kcal; 400\u2003mL) in a supine position. Next, we measured gastric emptying rate (GER), motility index (MI, antral contractions), and reflux index (RI, duodenogastric reflux) to assess gastroduodenal motility. Patients also completed a survey based on the seven\u2010point Likert scale both before and after drug administration.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold>Of the 37 cases, 19 and 18 were administered with acotiamide and placebo A respectively, significant difference was observed in GAR between the acotiamide and placebo groups (21.7%<jats:italic>vs<\/jats:italic>4.4%) after 400\u2003mL ingestion. GER significantly accelerated after treatment in the acotiamide group (<jats:italic>P<\/jats:italic>\u2003=\u20030.012), no significant differences were observed in MI and RI between the two groups. Improvement rates were 35.3 and 11.8% for the acotiamide and placebo groups.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold>Acotiamide significantly enhances GAR and GER in FD patients. Acotiamide may have therapeutic potential for FD patients.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2012.01897.x","type":"journal-article","created":{"date-parts":[[2012,3,5]],"date-time":"2012-03-05T21:25:19Z","timestamp":1330982719000},"page":"540","source":"Crossref","is-referenced-by-count":116,"title":["Therapeutic efficacy of acotiamide in patients with functional dyspepsia based on enhanced postprandial gastric accommodation and emptying: randomized controlled study evaluation by real\u2010time 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