{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T06:27:10Z","timestamp":1778567230807,"version":"3.51.4"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T00:00:00Z","timestamp":1332115200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2012,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold>Acotiamide hydrochloride (acotiamide), a novel selective acetylcholinesterase (AChE) inhibitor, has proven significantly effective in treating functional dyspepsia (FD) in clinical trials, particularly in alleviating meal\u2010related symptoms. In the present study, we examined the gastrointestinal prokinetic effects of acotiamide administered orally or intraduodenally in conscious dogs and investigated<jats:italic>in vivo<\/jats:italic>and<jats:italic>ex vivo<\/jats:italic>anti\u2010AChE activity of acotiamide to clarify its mechanism of prokinetic action.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold>Gastrointestinal motility was measured in conscious dogs with chronically implanted force transducers.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold>Oral administration of acotiamide stimulated postprandial gastroduodenal and colonic motor activities. Measurement of gastrointestinal motility showed that acotiamide, like itopride and mosapride, enhanced gastric antral motility. Further, acotiamide markedly improved clonidine (an \u03b1<jats:sub>2<\/jats:sub>\u2010adrenoceptor agonist)\u2010induced hypomotility in a dog model of gastric motor dysfunction. The postprandial gastric antral motility enhanced by acotiamide was completely abolished on treatment with the muscarinic receptor antagonist atropine. Results of an<jats:italic>in vivo<\/jats:italic>experiment on anti\u2010AChE activity showed clearly increased acetylcholine\u2010induced gastric motility on intraduodenal administration of acotiamide, just as observed with the AChE inhibitor neostigmine. Further, in<jats:italic>ex vivo<\/jats:italic>experiment, intraduodenal administration of acotiamide significantly inhibited AChE activity in canine gastric antrum.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold>Our findings revealed that acotiamide administered through the alimentary tract exerts gastroprokinetic action via cholinergic pathways by inhibiting AChE activity. These results may also confirm the mechanism of action in clinical efficacy of acotiamide on FD.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2012.01912.x","type":"journal-article","created":{"date-parts":[[2012,3,19]],"date-time":"2012-03-19T06:40:18Z","timestamp":1332139218000},"page":"566","source":"Crossref","is-referenced-by-count":36,"title":["Acotiamide, a new orally active acetylcholinesterase inhibitor, stimulates gastrointestinal motor activity in conscious 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