{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,6]],"date-time":"2026-10-06T13:37:57Z","timestamp":1791293877814,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T00:00:00Z","timestamp":1340064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2012,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> When sensitized epicutaneously and challenged orally with ovalbumin, Balb\/c mice develop allergen\u2010induced diarrhea. As mast cells play important roles in diarrhea, we studied whether allergic diarrhea could be alleviated with imatinib mesylate.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Balb\/c mice were sensitized and challenged with ovalbumin and treated orally with imatinib. Cytokine mRNA expressions were determined with quantitative RT\u2010PCR and numbers of small intestinal mast cells determined by staining for chloroacetate esterase and mucosal mast cell protease\u20101. Immunofluorescence staining was used to assess the intestinal CCL1 expression.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> Ovalbumin\u2010sensitized and challenged Balb\/c mice developed diarrhea, which was associated with increased number of mast cells and expression of interleukin (IL)\u20104 and \u201013, and chemokines CCL1 and CCL17 in the small intestine. Treatment with imatinib reduced the incidence of diarrhea, inhibited the development of mastocytosis and jejunal mRNA expression of IL\u201013, CCL1, CCL17 and CCL22. Mast cell\u2010deficient W\/W<jats:sup>\u2010V<\/jats:sup> mice, and surprisingly, also their mast cell\u2010competent control (+\/+) littermates failed to develop diarrhea as a response to ovalbumin. This strain\u2010dependent difference was associated with the inability of +\/+ and W\/W<jats:sup>\u2010V<\/jats:sup> mice to increase the number of intestinal mast cells and expression of IL\u20104, IL\u201013, CCL1 and CCL17 after ovalbumin challenge.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> Development of allergic diarrhea is associated with the ability of mice to develop intestinal mastocytosis. Imatinib inhibited the development of intestinal mastocytosis, reduced the incidence of diarrhea, and reduced the expression of IL\u201013, CCL1, and CCL17. Targeting intestinal mast cells could be a feasible approach to treat allergic diarrhea.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2012.01941.x","type":"journal-article","created":{"date-parts":[[2012,6,19]],"date-time":"2012-06-19T12:04:03Z","timestamp":1340107443000},"source":"Crossref","is-referenced-by-count":14,"title":["Imatinib mesylate alleviates diarrhea in a mouse model of intestinal allergy"],"prefix":"10.1111","volume":"24","author":[{"given":"K.","family":"Vaali","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Lappalainen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. H.","family":"Lin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. I.","family":"M\u00e4yr\u00e4np\u00e4\u00e4","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P. T","family":"Kovanen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Berstad","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. K.","family":"Eklund","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,6,19]]},"reference":[{"key":"e_1_2_10_2_2","doi-asserted-by":"publisher","DOI":"10.1172\/JCI19785"},{"key":"e_1_2_10_3_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1231488100"},{"key":"e_1_2_10_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2008.10.001"},{"key":"e_1_2_10_5_2","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2005.03.049"},{"key":"e_1_2_10_6_2","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.71.5.2430-2438.2003"},{"key":"e_1_2_10_7_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.4.2234"},{"key":"e_1_2_10_8_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2222.2009.03329.x"},{"key":"e_1_2_10_9_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra013339"},{"key":"e_1_2_10_10_2","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM200104053441409"},{"key":"e_1_2_10_11_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2004.04.046"},{"key":"e_1_2_10_12_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0301-472X(01)00659-2"},{"key":"e_1_2_10_13_2","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.200403-385OC"},{"key":"e_1_2_10_14_2","doi-asserted-by":"publisher","DOI":"10.1080\/00365520600815639"},{"key":"e_1_2_10_15_2","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.135.1.279"},{"key":"e_1_2_10_16_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V57.6.1088.1088"},{"key":"e_1_2_10_17_2","doi-asserted-by":"publisher","DOI":"10.1186\/1471-230X-9-33"},{"key":"e_1_2_10_18_2","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2004.029835"},{"key":"e_1_2_10_19_2","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2007.061274"},{"key":"e_1_2_10_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3024.1993.tb00572.x"},{"key":"e_1_2_10_21_2","doi-asserted-by":"publisher","DOI":"10.1038\/ni768"},{"key":"e_1_2_10_22_2","doi-asserted-by":"publisher","DOI":"10.1038\/365340a0"},{"key":"e_1_2_10_23_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001900"},{"key":"e_1_2_10_24_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0165-2427(98)00086-5"},{"key":"e_1_2_10_25_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.179.3.1740"},{"key":"e_1_2_10_26_2","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.177.10.6940"},{"key":"e_1_2_10_27_2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2002-02-0602"},{"key":"e_1_2_10_28_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00323.2007"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2982.2012.01941.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2982.2012.01941.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T21:35:28Z","timestamp":1698701728000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2982.2012.01941.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,6,19]]},"references-count":27,"journal-issue":{"issue":"7","published-print":{"date-parts":[[2012,7]]}},"alternative-id":["10.1111\/j.1365-2982.2012.01941.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2982.2012.01941.x","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,6,19]]}}}