{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T15:02:30Z","timestamp":1778511750927,"version":"3.51.4"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T00:00:00Z","timestamp":1339372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2012,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Inflammation may be detected in diverticular disease (DD), and fibrosis may also develop. We assessed the mucosal expression of bFGF, SD1, and TNF\u2010\u03b1 in DD according to the severity of the disease. Moreover, we assessed the response to therapy of these cytokines in acute uncomplicated diverticulitis (AUD).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Fifteen patients affected by AUD and seven patients affected by symptomatic uncomplicated diverticular disease (SUDD) were enrolled. Patients with asymptomatic diverticulosis (AD), segmental colitis associated with diverticulosis (SCAD), ulcerative colitis (UC), and healthy subjects (HC) served as control groups.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> The expression of bFGF, SD1, and TNF\u2010\u03b1 was significantly higher in diverticulitis than in healthy controls, in diverticulosis, and in uncomplicated diverticular disease. Cytokines were significantly higher in uncomplicated diverticular disease than in healthy controls. Cytokine expression in diverticulitis did not differ significantly from that of ulcerative colitis. After treatment, TNF\u2010\u03b1 expression dropped significantly.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> Mucosal TNF\u2010\u03b1 is overexpressed only in symptomatic DD, while SD1 and bFGF are already overexpressed in AD. Finally, TNF\u2010\u03b1 but not SD1 or bFGF expression seems to be influenced by the treatment in AUD.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2012.01946.x","type":"journal-article","created":{"date-parts":[[2012,6,11]],"date-time":"2012-06-11T08:55:21Z","timestamp":1339404921000},"page":"836","source":"Crossref","is-referenced-by-count":24,"title":["Mucosal expression of basic fibroblastic growth factor, Syndecan 1 and tumor necrosis factor\u2010alpha in diverticular disease of the colon: a case\u2013control study"],"prefix":"10.1111","volume":"24","author":[{"given":"A.","family":"Tursi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W.","family":"Elisei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G.","family":"Brandimarte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"G. 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