{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T00:12:47Z","timestamp":1793146367835,"version":"4.5.0"},"reference-count":29,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T00:00:00Z","timestamp":1341446400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Many physicians do not consider the diagnosis of bile acid malabsorption in patients with chronic diarrhea, or do not have access to testing. We examined yield of 23\u2010seleno\u201025\u2010homo\u2010tauro\u2010cholic acid (SeHCAT) scanning in chronic diarrhea patients, and attempted to identify predictors of a positive test.<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Consecutive patients with chronic diarrhea undergoing SeHCAT scan over a 7\u2010year period were identified retrospectively. Bile acid malabsorption was defined as present at a retention of &lt;15%. Medical records were reviewed to obtain information regarding proposed risk factors. Gastrointestinal symptoms were recorded, and patients were classified as having diarrhea\u2010predominant irritable bowel syndrome (IBS\u2010D) if they reported abdominal pain or discomfort. Independent risk factors were assessed using multivariate logistic regression, and odds ratios (ORs) with 99% confidence intervals (CIs) were calculated.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> Of 373 patients, 190 (50.9%) had bile acid malabsorption. Previous cholecystectomy (OR 2.51; 99% CI 1.10\u20135.77), terminal ileal resection or right hemicolectomy for Crohn\u2019s disease (OR 12.4; 99% CI 2.42\u201363.8), and terminal ileal resection or right hemicolectomy for other reasons (OR 7.94; 99% CI 1.02\u201361.6) were associated with its presence. Seventy\u2010seven patients had IBS\u2010D, and 21 (27.3%) tested positive. There were 168 patients with no risk factors for a positive SeHCAT scan, other than chronic diarrhea, and 63 (37.5%) had bile acid malabsorption.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> Bile acid malabsorption was present in 50% of patients undergoing SeHCAT scanning. Almost 40% of those without risk factors had evidence of bile acid malabsorption, and in those meeting criteria for IBS\u2010D prevalence was almost 30%.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2012.01953.x","type":"journal-article","created":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T06:13:21Z","timestamp":1341555201000},"page":"983","source":"Crossref","is-referenced-by-count":88,"title":["Prevalence of, and predictors of, bile acid malabsorption in outpatients with chronic diarrhea"],"prefix":"10.1111","volume":"24","author":[{"given":"D. J.","family":"Gracie","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. S.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Mumtaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. 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