{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T17:41:25Z","timestamp":1789753285879,"version":"4.0.1"},"reference-count":23,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2012,7,4]],"date-time":"2012-07-04T00:00:00Z","timestamp":1341360000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neurogastroenterology Motil"],"published-print":{"date-parts":[[2012,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p><jats:bold>Background\u2002<\/jats:bold> Describe the association of internal anal sphincter (IAS) relaxation with colonic high\u2010 amplitude peristaltic contractions (HAPCs).<\/jats:p><jats:p><jats:bold>Methods\u2002<\/jats:bold> Retrospective review of colon manometry tracings of children with constipation to determine the IAS relaxation characteristics associated with HAPC\u2019s (HAPC\u2010IASR) events and compare them to the those seen during the performance of the anorectal manometry (ARMRAIR) events.<\/jats:p><jats:p><jats:bold>Key Results\u2002<\/jats:bold> A total of 70 HAPC\u2010 IASRs were observed in 15 patients, 65 after bisacodyl, two during fasting and three after a meal. In 64% of events, the IAS relaxation started when the HAPC reached left colon and in 36% as proximal as the hepatic flexure. High\u2010 amplitude peristaltic contraction propagation seems to be important in HAPC\u2010IASR characteristics; those propagating distal to sigmoid colon demonstrated larger and longer IAS relaxation as well as lower residual pressure, but equivalent resting pressure compared with HAPC\u2019s ending proximal to sigmoid colon. Although IAS resting pressure was comparable for ARM\u2010RAIRs and HAPC\u2010IASRs, the duration and magnitude of anal relaxation was higher, and the anal residual pressure was lower in HAPC\u2010IASRs.<\/jats:p><jats:p><jats:bold>Conclusions &amp; Inferences\u2002<\/jats:bold> We demonstrated that IAS relaxation in constipated children is associated with HAPCs migrating in the proximal and distal colon; in most cases, starting when peristalsis is migrating through left colon and in an important proportion while migrating proximally. We also demonstrated that HAPC\u2010IASRs are different from ARM\u2010RAIRs suggesting a neurally mediated reflex. Finally, the IAS relaxation characteristics are highly dependent on the degree of propagation of HAPCs, which could have important implications in the understanding of defecation disorders.<\/jats:p>","DOI":"10.1111\/j.1365-2982.2012.01965.x","type":"journal-article","created":{"date-parts":[[2012,7,5]],"date-time":"2012-07-05T00:09:15Z","timestamp":1341446955000},"page":"1023","source":"Crossref","is-referenced-by-count":26,"title":["Internal anal sphincter relaxation associated with bisacodyl\u2010induced colonic high amplitude propagating contractions in children with constipation: a colo\u2010anal reflex?"],"prefix":"10.1111","volume":"24","author":[{"given":"L.","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Siddiqui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Nurko","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2012,7,4]]},"reference":[{"key":"e_1_2_9_2_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00341220"},{"key":"e_1_2_9_3_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01840.x"},{"key":"e_1_2_9_4_2","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(92)91957-A"},{"key":"e_1_2_9_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3476(05)80229-X"},{"key":"e_1_2_9_6_2","doi-asserted-by":"publisher","DOI":"10.1136\/gut.28.1.17"},{"key":"e_1_2_9_7_2","first-page":"G660","article-title":"Manometric investigation of high\u2010amplitude propagated contractile activity of the human colon","volume":"255","author":"Bassotti G","year":"1988","journal-title":"Am J Physiol"},{"key":"e_1_2_9_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1590-8658(01)80133-X"},{"key":"e_1_2_9_9_2","doi-asserted-by":"publisher","DOI":"10.1001\/archsurg.138.12.1302"},{"key":"e_1_2_9_10_2","doi-asserted-by":"publisher","DOI":"10.1159\/000075554"},{"key":"e_1_2_9_11_2","doi-asserted-by":"publisher","DOI":"10.1038\/ajg.2008.110"},{"key":"e_1_2_9_12_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2011.01870.x"},{"key":"e_1_2_9_13_2","doi-asserted-by":"publisher","DOI":"10.1364\/OE.17.022423"},{"key":"e_1_2_9_14_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2982.2010.01651.x"},{"key":"e_1_2_9_15_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1572-0241.2000.01839.x"},{"key":"e_1_2_9_16_2","doi-asserted-by":"publisher","DOI":"10.1097\/00004836-199212000-00011"},{"key":"e_1_2_9_17_2","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2009.121"},{"key":"e_1_2_9_18_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-199810000-00006"},{"key":"e_1_2_9_19_2","doi-asserted-by":"publisher","DOI":"10.1139\/y86-005"},{"key":"e_1_2_9_20_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2036.2009.04118.x"},{"key":"e_1_2_9_21_2","doi-asserted-by":"publisher","DOI":"10.1007\/s003840000259"},{"key":"e_1_2_9_22_2","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00286.2011"},{"key":"e_1_2_9_23_2","doi-asserted-by":"publisher","DOI":"10.3109\/00365529708996536"},{"key":"e_1_2_9_24_2","first-page":"1239","article-title":"Nitric oxide as a mediator of bisacodyl and phenolphthalein laxative action: induction of nitric oxide synthase","volume":"270","author":"Gaginella TS","year":"1994","journal-title":"J Pharmacol Exp Ther"}],"container-title":["Neurogastroenterology &amp; Motility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2982.2012.01965.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2982.2012.01965.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,30]],"date-time":"2023-10-30T07:45:45Z","timestamp":1698651945000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2982.2012.01965.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2012,7,4]]},"references-count":23,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2012,11]]}},"alternative-id":["10.1111\/j.1365-2982.2012.01965.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2982.2012.01965.x","archive":["Portico"],"relation":{},"ISSN":["1350-1925","1365-2982"],"issn-type":[{"value":"1350-1925","type":"print"},{"value":"1365-2982","type":"electronic"}],"subject":[],"published":{"date-parts":[[2012,7,4]]}}}