{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,11,11]],"date-time":"2023-11-11T00:33:54Z","timestamp":1699662834842},"reference-count":21,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,6,28]],"date-time":"2008-06-28T00:00:00Z","timestamp":1214611200000},"content-version":"vor","delay-in-days":10040,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[1981,1]]},"abstract":"<jats:p>Davaki P. &amp; Lantos P.L. (1981) <jats:italic>Neuropathology and Applied Neurobiology<\/jats:italic> 7,49\u201361<\/jats:p><jats:p>The development of brain tumours produced in rats by the intracerebral injection of neoplastic glial cells: a fine structural study<\/jats:p><jats:p>Tumours were produced by the intracerebral injection of a clone of glial cells derived from a glioma induced transplacentally by N\u2010ethyl\u2010N\u2010nitrosourea in a BD\u2010IX rat. The injection of 5 times 10<jats:sup>5<\/jats:sup> cells into the left frontal lobe resulted in a 100% incidence of tumours. To follow the development of the neoplasms, the brains were studied from 1 day to 4 weeks after injection. The tumours maintained their glial characters throughout, but their features changed with time. Ultrastructurally, they were pleomorphic: the proportion of fibrillary astrocytes, undifferentiated and intermediate cell types varied according to tumour size. When smaller (1 and 2 weeks), fibrillary astrocytes predominated, but when larger (3 and 4 weeks), the number of undifferentiated astrocytes considerably increased. A reproducible brain tumour model with a short latency has thus been established and characterized, which may be of use for chemo\u2010 and radiotherapeutic studies and for examining the mechanisms of cerebral oedema.<\/jats:p>","DOI":"10.1111\/j.1365-2990.1981.tb00231.x","type":"journal-article","created":{"date-parts":[[2008,5,12]],"date-time":"2008-05-12T10:12:39Z","timestamp":1210587159000},"page":"49-61","source":"Crossref","is-referenced-by-count":10,"title":["THE DEVELOPMENT OF BRAIN TUMOURS PRODUCED IN RATS BY THE INTRACEREBRAL INJECTION OF NEOPLASTIC GLIAL CELLS: A FINE STRUCTURAL STUDY*"],"prefix":"10.1111","volume":"7","author":[{"given":"PANAYOTA","family":"DAVAKI","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"P. 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Morphologic observations on rat tumors maintained in tissue and organ culture systems","volume":"31","author":"SIPE J.C.","year":"1974","journal-title":"Laboratory Investigation"},{"key":"e_1_2_1_20_1","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1242\/jcs.37.1.143","article-title":"Survival of cells implanted in the embryonic chick limb bud: a difference between normal and malignant rat brain cells","volume":"37","author":"TICKLE C.","year":"1979","journal-title":"Journal of Cell Science"},{"key":"e_1_2_1_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.23.1.101"},{"key":"e_1_2_1_22_1","first-page":"530","article-title":"Changes in surface morphology associated with ethylnitrosourea\u2010induced malignant transformation of cultured rat brain cells studied by scanning electron microscopy","volume":"59","author":"WINSLOW D.P.","year":"1978","journal-title":"British Journal of Experimental Pathology"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2990.1981.tb00231.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2990.1981.tb00231.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,11,10]],"date-time":"2023-11-10T18:45:39Z","timestamp":1699641939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2990.1981.tb00231.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1981,1]]},"references-count":21,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1981,1]]}},"alternative-id":["10.1111\/j.1365-2990.1981.tb00231.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2990.1981.tb00231.x","archive":["Portico"],"relation":{},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[1981,1]]}}}