{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T02:25:03Z","timestamp":1770431103956,"version":"3.49.0"},"reference-count":48,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2004,2,6]],"date-time":"2004-02-06T00:00:00Z","timestamp":1076025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2004,6]]},"abstract":"<jats:p>Cerebral amyloid angiopathy is one of the characteristics of Alzheimer's disease (AD) and this accumulation of fibrillar amyloid\u2010\u03b2 (\u0391\u03b2) in the vascular wall is accompanied by marked vascular damage. <jats:italic>In vitro<\/jats:italic>, A\u03b2<jats:sub>1\u221240<\/jats:sub> carrying the \u2018Dutch\u2019 mutation (DA\u03b2<jats:sub>1\u221240<\/jats:sub>) induces degeneration of cultured human brain pericytes (HBP). To identify possible intracellular mediators of A\u03b2\u2010induced cell death, a comparative cDNA expression array was performed to detect differential gene expression of A\u03b2\u2010treated vs. untreated HBP. Messenger RNA expression of cyclin D1, integrin \u03b24, defender against cell death\u20101, neuroleukin, thymosin \u03b210, and integrin \u03b15 were increased in DA\u03b2<jats:sub>1\u221240<\/jats:sub>\u2010treated HBP, whereas insulin\u2010like growth factor binding protein\u20102 mRNA expression was decreased. Corresponding protein expression was investigated in AD and control brains to explore a potential role for these proteins in pathological lesions of the AD brain. Cyclin D1 expression was increased in cerebral amyloid angiopathy and cells in a perivascular position, suggesting that the cell cycle may be disturbed during A\u03b2\u2010mediated degeneration of cerebrovascular cells. Moreover, cyclin D1 expression, but also that of integrin \u03b24, defender against cell death\u20101, neuroleukin and thymosin \u03b210 was found in a subset of senile plaques, suggesting a role for these proteins in the pathogenesis of senile plaques.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2004.00536.x","type":"journal-article","created":{"date-parts":[[2004,12,27]],"date-time":"2004-12-27T12:06:36Z","timestamp":1104149196000},"page":"279-291","source":"Crossref","is-referenced-by-count":16,"title":["Differential gene expression in human brain pericytes induced by amyloid\u2010\u03b2 protein"],"prefix":"10.1111","volume":"30","author":[{"given":"A. A. M.","family":"Rensink","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Otte\u2010H\u00f6ller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H. J. ten","family":"Donkelaar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. M. W.","family":"De Waal","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"B.","family":"Kremer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. M.","family":"Verbeek","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2004,2,6]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(93)90021-E"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00311383"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1997.68031135.x"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-017-1007-7_16"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.2111584"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.7.2996"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.36.20887"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199756070-00001"},{"key":"e_1_2_6_10_2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1007\/s00401-002-0585-x","article-title":"Expression of the cytokine leukemia inhibitory factor and pro\u2010apoptotic insulin\u2010like growth factor binding protein\u20103 in Alzheimer's disease","volume":"104","author":"Rensink AAM","year":"2002","journal-title":"Acta Neuropathol"},{"key":"e_1_2_6_11_2","doi-asserted-by":"crossref","unstructured":"RensinkAAM Otte\u2010HollerI De BoerR Ten DonkelaarHJ De WaalRMW VerbeekMM KremerB.Insulin inhibits amyloid\u2010induced cell death in cultured human brain pericytes.Neurobiol Aging2004;25:93\u2013103","DOI":"10.1016\/S0197-4580(03)00039-3"},{"key":"e_1_2_6_12_2","first-page":"372","article-title":"Induction of alpha\u2010smooth muscle actin expression in cultured human brain pericytes by transforming growth factor\u2010beta 1","volume":"144","author":"Verbeek MM","year":"1994","journal-title":"Am J Pathol"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.41.4.479"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.18-08-02801.1998"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050665"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(02)00132-X"},{"key":"e_1_2_6_17_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.8.678"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.1007\/s007020050104"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-20-08747.1999"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.13.15.2225"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(99)00509-1"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.3109\/13506129909007321"},{"key":"e_1_2_6_23_2","first-page":"167","article-title":"Thymosin beta\u201010 accelerates apoptosis","volume":"41","author":"Hall AK","year":"1995","journal-title":"Cell Mol Biol Res"},{"key":"e_1_2_6_24_2","first-page":"4","article-title":"Molecular pathogenesis of beta\u2010amyloidosis in Alzheimer's disease and other cerebral amyloidoses","volume":"72","author":"Maury CP","year":"1995","journal-title":"Laboratory Invest"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2003.01524.x"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1007\/BF00190565"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90241-0"},{"key":"e_1_2_6_28_2","doi-asserted-by":"publisher","DOI":"10.1016\/0022-510X(88)90031-7"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1161\/01.STR.28.4.858"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(96)13147-5"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0730742.x"},{"key":"e_1_2_6_32_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(02)00058-X"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10292"},{"key":"e_1_2_6_34_2","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.490300411"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.13.10.6367"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1995.tb00122.x"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1038\/332454a0"},{"key":"e_1_2_6_38_2","first-page":"2960","article-title":"Tumor cell autocrine motility factor is the neuroleukin\/phosphohexose isomerase polypeptide","volume":"56","author":"Watanabe H","year":"1996","journal-title":"Cancer Res"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1080\/00034980120111145"},{"key":"e_1_2_6_40_2","doi-asserted-by":"publisher","DOI":"10.1126\/science.3764429"},{"key":"e_1_2_6_41_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.1996.tb01130.x"},{"key":"e_1_2_6_42_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0197-4580(98)00077-3"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.40.4.632"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(96)01356-X"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1191\/096032799678839815"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1007\/s004010050474"},{"key":"e_1_2_6_47_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001756-199601310-00068"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.84.9.3033"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3940(01)01618-4"}],"container-title":["Neuropathology and Applied Neurobiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2990.2004.00536.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-2990.2004.00536.x","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-2990.2004.00536.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,14]],"date-time":"2023-10-14T15:38:59Z","timestamp":1697297939000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-2990.2004.00536.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2004,2,6]]},"references-count":48,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2004,6]]}},"alternative-id":["10.1111\/j.1365-2990.2004.00536.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-2990.2004.00536.x","archive":["Portico"],"relation":{},"ISSN":["0305-1846","1365-2990"],"issn-type":[{"value":"0305-1846","type":"print"},{"value":"1365-2990","type":"electronic"}],"subject":[],"published":{"date-parts":[[2004,2,6]]}}}