{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T11:53:05Z","timestamp":1791114785739,"version":"4.1.0"},"reference-count":43,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2004,7,9]],"date-time":"2004-07-09T00:00:00Z","timestamp":1089331200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2005,2]]},"abstract":"<jats:p>The idiopathic inflammatory myopathies (IIM) are a group of autoimmune diseases characterized by chronic lymphocytic and macrophagic infiltration in muscle. Because the mechanism for recruitment of these cells probably involves chemokines, we focused on the study of the expression pattern of some \u03b2 chemokines and receptors because it may provide a basis for selective immunotherapy. The expression of CCL3 (MIP\u20101\u03b1), CCL4 (MIP\u20101\u03b2), CCL5 (RANTES) and their main receptors (CCR1 and CCR5) was studied by semi\u2010quantitative reverse transcriptase polymerase chain reaction (RT\u2010PCR) and immunohistochemistry in a series of 16 IIM and five controls (four normal muscles and one tonsil). Except for CCL5, strong expression was observed by RT\u2010PCR with all molecules in all IIM subtypes in comparison to control muscle. Immunohistochemistry revealed diffuse CCL4 expression in all vessels in dermatomyositis. In both polymyositis and sporadic inclusion body myositis (s\u2010IBM) it was restricted to vessels in the vicinity of inflammatory exudates. CCL5 expression was low, restricted to a few inflammatory cells in all IIM; CCR1 expression was mainly restricted to macrophages and s\u2010IBM endothelial cells, whereas CCR5 was localized in inflammatory cells invading non\u2010necrotic muscle fibres. Expressions of both receptors were also recorded in few muscle fibres. In conclusion, the upregulation of \u03b2 chemokines and receptors in IIM and their differential expression by various cells may contribute to chronic inflammation and to the peculiar distribution of inflammatory exudates in these diseases.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2004.00591.x","type":"journal-article","created":{"date-parts":[[2005,1,4]],"date-time":"2005-01-04T11:38:05Z","timestamp":1104838685000},"page":"70-79","source":"Crossref","is-referenced-by-count":50,"title":["Expression of the \u03b2 chemokines CCL3, CCL4, CCL5 and their receptors in idiopathic inflammatory myopathies"],"prefix":"10.1111","volume":"31","author":[{"given":"M.","family":"Civatte","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Bartoli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"N.","family":"Schleinitz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Chetaille","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. 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