{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T14:24:55Z","timestamp":1790519095515,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T00:00:00Z","timestamp":1145923200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2006,6]]},"abstract":"<jats:p>Previous studies investigating the serotonin transporter (SERT) in depression have been inconsistent and included a large proportion of subjects who had committed suicide. In Alzheimer's disease studies have generally reported a reduction in SERT density but have not compared Alzheimer's disease subjects with and without comorbid major depression. We conducted a <jats:italic>post mortem<\/jats:italic> study of SERT density in the prefrontal cortex in normal elderly, a group of elderly depressed subjects and in Alzheimer's disease subjects with and without major depression. A <jats:italic>post mortem<\/jats:italic> study comparing SERT density in the prefrontal cortex in elderly controls (<jats:italic>n<\/jats:italic>\u2003=\u200310), subjects with major depression (<jats:italic>n<\/jats:italic>\u2003=\u20038) and subjects with Alzheimer's disease with (<jats:italic>n<\/jats:italic>\u2003=\u20039) and without (<jats:italic>n<\/jats:italic>\u2003=\u20035) comorbid major depression. We used autoradiography to measure the density of [<jats:sup>3<\/jats:sup>H]CN\u2010IMI binding (non\u2010specific binding determined with citalopram) to the SERT in the prefrontal cortex. We found a marked reduction in specific SERT binding in the prefrontal cortex in Alzheimer's disease subjects compared with both control (<jats:italic>P<\/jats:italic>\u2003=\u20030.002) and depressed subjects (<jats:italic>P<\/jats:italic>\u2003=\u20030.004) but no difference in SERT binding between depressed and control subjects or between Alzheimer's disease subjects with and without depression. Our study confirms previous reports of a reduction in SERT binding in Alzheimer's disease but indicates this reduction is not greater in Alzheimer's disease subjects who also have had major depression. In a group of subjects more typical of late\u2010life depression we did not identify any alterations in SERT density.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2006.00728.x","type":"journal-article","created":{"date-parts":[[2006,4,25]],"date-time":"2006-04-25T13:16:46Z","timestamp":1145971006000},"page":"296-303","source":"Crossref","is-referenced-by-count":46,"title":["A study of the serotonin transporter in the prefrontal cortex in late\u2010life depression and Alzheimer's disease with and without depression"],"prefix":"10.1111","volume":"32","author":[{"given":"A. J.","family":"Thomas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Hendriksen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Piggott","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I. 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