{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T21:31:37Z","timestamp":1790976697296,"version":"4.1.0"},"reference-count":20,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2006,9,15]],"date-time":"2006-09-15T00:00:00Z","timestamp":1158278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2006,10]]},"abstract":"<jats:p>Lysosome\u2010associated membrane protein 1 (LAMP\u20101) is a glycoprotein highly expressed in lysosomal membranes. The present study was initiated to test LAMP\u20101 mRNA and protein levels in <jats:italic>post mortem<\/jats:italic> frontal cortex (area 8) of Alzheimer\u2019s disease (AD) stages I\u2013IIA\/B and stages V\u2013VIC of Braak and Braak, compared with age\u2010matched controls. TaqMan PCR assays and Western blots demonstrated upregulation of LAMP\u20101 mRNA and protein in the cerebral cortex in ADVC. In addition, immunohistochemical studies have shown increased LAMP\u20101 immunoreactivity in neurones, and in glial cells surrounding senile plaques, in AD cases. Interestingly, LAMP\u20101 immunoreactivity has little correlation with phosphorylated tau deposition and neurofibrillary tangles (NFTs), as neurones with NFTs were rarely LAMP\u20101 immunoreactive. In contrast, LAMP\u20101 expression was enhanced in neurones with granulovacuolar degeneration. Finally, LAMP\u20101 occurred in microglia and multinucleated giant cells in one AD case in whom amyloid burden was cleared following \u03b2A\u2010peptide immunization. These findings support the participation of lysosomes in \u03b2A\u2010amyloid and, probably, in hyperphosphorylated tau turnover in AD.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2006.00756.x","type":"journal-article","created":{"date-parts":[[2006,9,15]],"date-time":"2006-09-15T08:57:21Z","timestamp":1158310641000},"page":"505-516","source":"Crossref","is-referenced-by-count":83,"title":["Lysosome\u2010associated membrane protein 1 (LAMP\u20101) in Alzheimer\u2019s disease"],"prefix":"10.1111","volume":"32","author":[{"given":"M.","family":"Barrachina","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Buesa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2006,9,15]]},"reference":[{"key":"e_1_2_6_2_2","first-page":"47","volume-title":"Neurodegeneration: The Molecular Pathology of Dementia and Movement Disorders.","author":"Duyckaerts C","year":"2003"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.1023\/A:1007675508413"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.88.24.10998"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199606000-00004"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1016\/0896-6273(95)90324-0"},{"key":"e_1_2_6_7_2","doi-asserted-by":"crossref","first-page":"6142","DOI":"10.1523\/JNEUROSCI.17-16-06142.1997","article-title":"Increased neuronal endocytosis and protease delivery to early endosomes in sporadic Alzheimer\u2019s disease: neuropathologic evidence for a mechanism of increased beta\u2010amyloidogenesis","volume":"17","author":"Cataldo AM","year":"1997","journal-title":"J Neurosci"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/63.8.821"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1006\/exnr.1999.7087"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2000.0741469.x"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.1006\/mcne.2001.1051"},{"key":"e_1_2_6_12_2","doi-asserted-by":"crossref","first-page":"18911","DOI":"10.1016\/S0021-9258(18)37369-1","article-title":"Isolation and characterization of human lysosomal membrane glycoproteins, h\u2010lamp\u20101 and h\u2010lamp\u20102. 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