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Complete lack of merlin is also found in spontaneous schwannomas and meningiomas. As the events leading to schwannoma development are largely unknown we investigated the differences in gene expression between schwannoma cells from NF2 patients and normal human primary Schwann cells by cDNA array analysis. We identified 41 genes whose expression levels differed by more than factor 2. Most of these clones were corroborated by real\u2010time reverse transcription polymerase chain reaction analysis. By this method a total of seven genes with increased and seven genes with decreased mRNA levels in schwannoma compared with normal Schwann cells could be identified. Regulated clones, some of which not been described in Schwann cells earlier, included matrix metalloproteinase\u2019s, growth factors, growth factor receptors and tyrosine kinases.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2006.00769.x","type":"journal-article","created":{"date-parts":[[2006,11,3]],"date-time":"2006-11-03T01:05:48Z","timestamp":1162515948000},"page":"605-614","source":"Crossref","is-referenced-by-count":35,"title":["Differential gene expression between human schwannoma and control Schwann cells"],"prefix":"10.1111","volume":"32","author":[{"given":"C. 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