{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T02:07:50Z","timestamp":1792030070449,"version":"4.4.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T00:00:00Z","timestamp":1169424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2007,4]]},"abstract":"<jats:p>Invasive meningiomas disrupt the pial\u2013glial basement membrane. This membrane is closely attached to the subpial glial endfeet forming the glia limitans. The fate of subpial astrocytes during the course of brain invasion by meningiomas is not known. In the present study we immunolabelled sections of 35 brain\u2010invasive meningiomas (14 meningothelial meningiomas WHO grade I, 11 atypical WHO grade II and 10 anaplastic WHO grade III) using anti\u2010collagen IV to label basement membrane material, and antibodies against astrocytic markers CD44, SPARC (secreted protein, acidic and rich in cysteine) and glial fibrillary acidic protein (GFAP). Astrocytes were present at the tumour\u2013brain interface of 14\/14 WHO grade I meningiomas, 9\/11 WHO grade II tumours and 9\/10 WHO grade III tumours. The presence of astrocytes was associated with an intact basement membrane in 11\/14 WHO grade I meningiomas (<jats:italic>P\u2003<\/jats:italic>&lt;\u20030.01), 6\/9 WHO grade II tumours, and 6\/9 WHO grade III tumours. However, tumour embedded in deep brain parenchyma lacked both an astrocytic reaction and basement membrane material. In conclusion, astrocytes eventually disappear from the tumour\u2013brain interface during the course of meningioma infiltration. This observation might indicate that the survival of subpial astrocytes is dependent on an intact pial\u2013glial basement membrane.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2006.00792.x","type":"journal-article","created":{"date-parts":[[2007,1,22]],"date-time":"2007-01-22T11:07:55Z","timestamp":1169464075000},"page":"163-168","source":"Crossref","is-referenced-by-count":24,"title":["The astrocytic response towards invasive meningiomas"],"prefix":"10.1111","volume":"33","author":[{"given":"L.","family":"Zeltner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Schittenhelm","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Mittelbronn","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Roser","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Tatagiba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Mawrin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Y. 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