{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T05:27:13Z","timestamp":1791091633351,"version":"4.1.0"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T00:00:00Z","timestamp":1219104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2009,2]]},"abstract":"<jats:p> <jats:bold>Aims<\/jats:bold>: To determine in the cerebellum in variant Creutzfeldt\u2013Jakob disease (vCJD): (i) whether the pathology affected all laminae; (ii) the spatial topography of the pathology along the folia; (iii) spatial correlations between the pathological changes; and (iv) whether the pathology was similar to that of the common methionine\/methionine Type 1 subtype of sporadic CJD. <jats:bold>Methods<\/jats:bold>: Sequential cerebellar sections of 15 cases of vCJD were stained with haematoxylin and eosin, or immunolabelled with monoclonal antibody 12F10 against prion protein (PrP) and studied using spatial pattern analysis. <jats:bold>Results<\/jats:bold>: Loss of Purkinje cells was evident compared with control cases. Densities of the vacuolation and the protease\u2010resistant form of prion protein (PrP<jats:sup>Sc<\/jats:sup>) (diffuse and florid plaques) were greater in the granule cell layer (GL) than the molecular layer (ML). In the ML, vacuoles and PrP<jats:sup>Sc<\/jats:sup> plaques occurred in clusters regularly distributed along the folia with larger clusters of vacuoles and diffuse plaques in the GL. There was a negative spatial correlation between the vacuoles and the surviving Purkinje cells in the ML. There was a positive spatial correlation between the vacuoles and diffuse PrP<jats:sup>Sc<\/jats:sup> plaques in the ML and GL. <jats:bold>Conclusions<\/jats:bold>: (i) all laminae were affected by the pathology, the GL more severely than the ML; (ii) the pathology was topographically distributed along the folia especially in the Purkinje cell layer and ML; (iii) pathological spread may occur in relation to the loop of anatomical connections involving the cerebellum, thalamus, cerebral cortex and pons; and (iv) there were pathological differences compared with methionine\/methionine Type 1 sporadic CJD.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2008.00979.x","type":"journal-article","created":{"date-parts":[[2008,8,19]],"date-time":"2008-08-19T07:28:17Z","timestamp":1219130897000},"page":"36-45","source":"Crossref","is-referenced-by-count":19,"title":["A quantitative study of the pathological changes in the cerebellum in 15 cases of variant Creutzfeldt\u2013Jakob disease (vCJD)"],"prefix":"10.1111","volume":"35","author":[{"given":"R. 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