{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:37:32Z","timestamp":1773898652443,"version":"3.50.1"},"reference-count":69,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2011,10,27]],"date-time":"2011-10-27T00:00:00Z","timestamp":1319673600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2011,12]]},"abstract":"<jats:p>H. Madarame, T. Seuberlich, C. Abril, A. Zurbriggen, M. Vandevelde and A. Oevermann (2011)<jats:italic>Neuropathology and Applied Neurobiology<\/jats:italic><jats:bold>37,<\/jats:bold>753\u2013767<\/jats:p><jats:p><jats:bold>The distribution of E\u2010cadherin expression in listeric rhombencephalitis of ruminants indicates its involvement in<jats:italic>Listeria monocytogenes<\/jats:italic>neuroinvasion<\/jats:bold><\/jats:p><jats:p><jats:bold>Aim:<\/jats:bold>To investigate the expression of E\u2010cadherin, a major host cell receptor for<jats:italic>Listeria monocytogenes<\/jats:italic>(LM) internalin A, in the ruminant nervous system and its putative role in brainstem invasion and intracerebral spread of LM in the natural disease.<jats:bold>Methods:<\/jats:bold>Immunohistochemistry and double immunofluorescence was performed on brains, cranial nerves and ganglia of ruminants with and without natural LM rhombencephalitis using antibodies against E\u2010cadherin, protein gene product 9.5, myelin\u2010associated glycoprotein and LM.<jats:bold>Results:<\/jats:bold>In the ruminant brain, E\u2010cadherin is expressed in choroid plexus epithelium, meningothelium and restricted neuropil areas of the medulla, but not in the endothelium. In cranial nerves and ganglia, E\u2010cadherin is expressed in satellite cells and myelinating Schwann cells. Expression does not differ between ruminants with or without listeriosis and does not overlap with the presence of microabscesses in the medulla. LM is observed in phagocytes, axons, Schwann cells, satellite cells and ganglionic neurones.<jats:bold>Conclusion:<\/jats:bold>Our results support the view that the specific ligand\u2013receptor interaction between LM and host E\u2010cadherin is involved in the neuropathogenesis of ruminant listeriosis. They suggest that oral epithelium and Schwann cells expressing E\u2010cadherin provide a port of entry for free bacteria offering a site of primary intracellular replication, from where the bacterium may invade the axonal compartment by cell\u2010to\u2010cell spread. As E\u2010cadherin expression in the ruminant central nervous system is weak, only very locally restricted and not related to the presence of microabscesses, it is likely that further intracerebral spread is independent of E\u2010cadherin and relies primarily on axonal spread.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2011.01183.x","type":"journal-article","created":{"date-parts":[[2011,4,12]],"date-time":"2011-04-12T10:49:33Z","timestamp":1302605373000},"page":"753-767","source":"Crossref","is-referenced-by-count":16,"title":["The distribution of E\u2010cadherin expression in listeric rhombencephalitis of ruminants indicates its involvement in<i>Listeria monocytogenes<\/i>neuroinvasion"],"prefix":"10.1111","volume":"37","author":[{"given":"H.","family":"Madarame","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"T.","family":"Seuberlich","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"C.","family":"Abril","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Zurbriggen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M.","family":"Vandevelde","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Oevermann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2011,10,27]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"crossref","DOI":"10.1155\/2010\/632513","article-title":"Rhombencephalitis caused by Listeria monocytogenes in humans and ruminants: a Zoonosis on the rise?","volume":"2010","author":"Oevermann A","year":"2010","journal-title":"Interdiscip Perspect Infect Dis"},{"key":"e_1_2_6_3_2","doi-asserted-by":"publisher","DOI":"10.3201\/eid0803.010195"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.2807\/esm.11.06.00633-en"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1090-0233(97)80005-6"},{"key":"e_1_2_6_6_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2005.tb00519.x"},{"key":"e_1_2_6_7_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2009.00292.x"},{"key":"e_1_2_6_8_2","doi-asserted-by":"publisher","DOI":"10.1016\/j.vetmic.2008.01.015"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1177\/030098587701400401"},{"key":"e_1_2_6_10_2","first-page":"125","article-title":"Observation on the presence of Listeria monocytogenes in axons","volume":"36","author":"Otter A","year":"1989","journal-title":"Acta Microbiol Hung"},{"key":"e_1_2_6_11_2","first-page":"61","article-title":"Zur Neuropathogenese der Listeriose. 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