{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T17:34:38Z","timestamp":1788888878387,"version":"build-2803163510"},"reference-count":70,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2012,7,6]],"date-time":"2012-07-06T00:00:00Z","timestamp":1341532800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2012,8]]},"abstract":"<jats:p>M. Ndung'u, W. H\u00e4rtig, F. Wegner, J. M. Mwenda, R. W. C. Low, R. O. Akinyemi and R. N. Kalaria (2012) <jats:italic>Neuropathology and Applied Neurobiology<\/jats:italic><jats:bold>38,<\/jats:bold> 487\u2013499<\/jats:p><jats:p><jats:bold>Cerebral amyloid \u03b2(42) deposits and microvascular pathology in ageing baboons<\/jats:bold><\/jats:p><jats:p><jats:bold>Background:<\/jats:bold> Previous studies have extensively reported the deposition of amyloid \u03b2 (A\u03b2) peptide with carboxyl\u2010 and amino\u2010terminal heterogeneity in cortical and cerebrovascular deposits in Alzheimer's disease (AD) and in non\u2010human primates except baboons. <jats:bold>Methods:<\/jats:bold> We examined the immunocytochemical distribution of A\u03b2 peptides and A\u03b2 oligomers in brain tissue from three subspecies of 18\u2010 to 28\u2010year\u2010old baboons (<jats:italic>Papio<\/jats:italic>) and in other monkeys including the squirrel (<jats:italic>Saimiri sciureus<\/jats:italic>) and rhesus (<jats:italic>Macaca mulatta<\/jats:italic>) for comparison. <jats:bold>Results:<\/jats:bold> A general preponderance of A\u03b2(42) in parenchymal deposits and many vascular deposits in all cortical lobes was evident in the baboons. A\u03b2 oligomeric immunoreactivity was also apparent like to amyloid plaques. We found that the amino acid sequence of the A\u03b2 domain of the baboon amyloid precursor protein is similar to that of man. In contrast to A\u03b2, immunoreactivity to hyperphosphorylated tau protein was largely intracellular and rare in these baboons. Brain tissues from squirrel and rhesus monkeys examined in parallel exhibited mostly vascular and parenchymal deposits containing A\u03b2(42) peptides. Our results were comparable to AD, but showed that even in younger monkeys exhibiting few deposits, A\u03b2(42) was evident in both parenchymal deposits and cerebral amyloid angiopathy. Perivascular amyloid deposits were frequent and often accompanied by microvascular abnormalities in the form of collapsed degenerated capillaries. <jats:bold>Conclusions:<\/jats:bold> Similar to other primates above and below in the phylogenetic order, our observations and evaluation of the literature implicate pathogenicity of A\u03b2(42) peptide associated with microvascular degeneration in baboons. 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