{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T12:07:42Z","timestamp":1792670862049,"version":"4.5.0"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2013,1,25]],"date-time":"2013-01-25T00:00:00Z","timestamp":1359072000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2013,2]]},"abstract":"<jats:p>G. G. Kovacs, A. J. M. Rozemuller, J. C. van Swieten, E. Gelpi, K. Majtenyi, S. Al\u2010Sarraj, C. Troakes, I. B\u00f3di, A. King, T. Hortob\u00e1gyi, M. M. Esiri, O. Ansorge, G. Giaccone, I. Ferrer, T. Arzberger, N. Bogdanovic, T. Nilsson, I. Leisser, I. Alafuzoff, J. W. Ironside, H. Kretzschmar and H. Budka (2013) <jats:italic>Neuropathology and Applied Neurobiology<\/jats:italic><jats:bold>39,<\/jats:bold> 166\u2013178<\/jats:p><jats:p><jats:bold>Neuropathology of the hippocampus in FTLD\u2010Tau with Pick bodies: a study of the BrainNet Europe Consortium<\/jats:bold><\/jats:p><jats:p><jats:bold>Aims:<\/jats:bold> Frontotemporal lobar degeneration with Pick bodies (Pick's disease) is characterized by the presence of tau immunoreactive spherical structures in the cytoplasm of neurones. In view of confusion about the molecular pathology of Pick's disease, we aimed to evaluate the spectrum of tau pathology and concomitant neurodegeneration\u2010associated protein depositions in the characteristically affected hippocampus. <jats:bold>Methods:<\/jats:bold> We evaluated immunoreactivity (IR) for tau (AT8, 3R, 4R), \u03b1\u2010synuclein, TDP43, p62, and ubiquitin in the hippocampus, entorhinal and temporal cortex in 66 archival cases diagnosed neuropathologically as Pick's disease. <jats:bold>Results:<\/jats:bold> Mean age at death was 68.2 years (range 49\u201396). Fifty\u2010two (79%) brains showed 3R immunoreactive spherical inclusions in the granule cells of the dentate gyrus. These typical cases presented mainly with the behavioural variant of frontotemporal dementia, followed by progressive aphasia, mixed syndromes or early memory disturbance. \u03b1\u2010Synuclein IR was seen only in occasional spherical tau\u2010positive inclusions, TDP\u201043 IR was absent, and 4R IR was present only as neurofibrillary tangles in pyramidal neurones. A\u03b2 IR was observed in 16 cases; however, the overall level of Alzheimer's disease\u2010related alterations was mainly low or intermediate (<jats:italic>n<\/jats:italic>\u2003=\u20033). Furthermore, we identified six cases with unclassifiable tauopathy. <jats:bold>Conclusions:<\/jats:bold> (i) Pick's disease may occur also in elderly patients and is characterized by a relatively uniform pathology with 3R tau inclusions particularly in the granule cells of dentate gyrus; (ii) even minor deviation from these morphological criteria suggests a different disorder; and (iii) immunohistological revision of archival cases expands the spectrum of tauopathies that require further classification.<\/jats:p>","DOI":"10.1111\/j.1365-2990.2012.01272.x","type":"journal-article","created":{"date-parts":[[2012,4,4]],"date-time":"2012-04-04T11:39:27Z","timestamp":1333539567000},"page":"166-178","source":"Crossref","is-referenced-by-count":69,"title":["Neuropathology of the hippocampus in FTLD\u2010Tau with Pick bodies: a study of the BrainNet Europe Consortium"],"prefix":"10.1111","volume":"39","author":[{"given":"G. 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