{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T23:29:48Z","timestamp":1790033388423,"version":"4.0.1"},"reference-count":26,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2013,7,9]],"date-time":"2013-07-09T00:00:00Z","timestamp":1373328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Deutsche Krebshilfe (Max-Eder-Nachwuchsgruppenprogramm)"},{"DOI":"10.13039\/501100003390","name":"Fritz-Thyssen-Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100003390","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100008426","name":"Friedrich-Baur-Stiftung","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100008426","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Neuropathology Appl Neurobio"],"published-print":{"date-parts":[[2013,8]]},"abstract":"<jats:sec><jats:title>Aims<\/jats:title><jats:p>Adult neurogenesis is well described in the subventricular zone of the lateral ventricle walls and in the subgranular zone of the hippocampal dentate gyrus. However, recent studies indicate that self\u2010renewal of neural stem cells (<jats:styled-content style=\"fixed-case\">NSCs<\/jats:styled-content>) is not restricted to these niches, but that diverse areas of the adult brain are capable of generating new neurones and responding to various pathological alterations. In particular, <jats:styled-content style=\"fixed-case\">NSCs<\/jats:styled-content> have been identified in circumventricular organs (<jats:styled-content style=\"fixed-case\">CVOs<\/jats:styled-content>) of the adult mouse brain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In order to detect possible neural stem or progenitor cells in <jats:styled-content style=\"fixed-case\">CVOs<\/jats:styled-content> of the human brain, we analysed <jats:italic>post mortem<\/jats:italic> human brain tissue from patients without neuropathological changes (<jats:italic>n<\/jats:italic>\u2009=\u200916) and brains from patients with ischaemic stroke (<jats:italic>n<\/jats:italic>\u2009=\u200916).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In all analysed <jats:styled-content style=\"fixed-case\">CVOs<\/jats:styled-content> (area postrema, median eminence, pineal gland and neurohypophysis) we observed cells with expression of early <jats:styled-content style=\"fixed-case\">NSC<\/jats:styled-content> markers, such as <jats:styled-content style=\"fixed-case\">GFAP<\/jats:styled-content>, nestin, vimentin, <jats:styled-content style=\"fixed-case\">OLIG<\/jats:styled-content>2 and <jats:styled-content style=\"fixed-case\">PSA\u2010NCAM<\/jats:styled-content>, with some of them coexpressing <jats:styled-content style=\"fixed-case\">Ki<\/jats:styled-content>67 as a marker of cell proliferation. Importantly, stroke patients displayed an up to fivefold increase with respect to the relative number of <jats:styled-content style=\"fixed-case\">Ki<\/jats:styled-content>67\u2010 and <jats:styled-content style=\"fixed-case\">OLIG<\/jats:styled-content>2\u2010expressing cells within their <jats:styled-content style=\"fixed-case\">CVOs<\/jats:styled-content>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our findings are compatible with a scenario where <jats:styled-content style=\"fixed-case\">CVOs<\/jats:styled-content> may serve as a further source of <jats:styled-content style=\"fixed-case\">NSCs<\/jats:styled-content> in the adult human brain and may contribute to neurogenesis and brain plasticity in the context of brain injury.<\/jats:p><\/jats:sec>","DOI":"10.1111\/j.1365-2990.2012.01301.x","type":"journal-article","created":{"date-parts":[[2012,9,17]],"date-time":"2012-09-17T12:34:07Z","timestamp":1347885247000},"page":"510-518","source":"Crossref","is-referenced-by-count":40,"title":["Recruitment of neural precursor cells from circumventricular organs of patients with cerebral ischaemia"],"prefix":"10.1111","volume":"39","author":[{"given":"V.","family":"Sanin","sequence":"first","affiliation":[{"name":"Center for Neuropathology and Prion Research Ludwig\u2010Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Hee\u00df","sequence":"additional","affiliation":[{"name":"Center for Neuropathology and Prion Research Ludwig\u2010Maximilians\u2010University  Munich Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H. 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