{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T06:59:07Z","timestamp":1773298747166,"version":"3.50.1"},"reference-count":49,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T00:00:00Z","timestamp":1144368000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Paediatric Perinatal Epid"],"published-print":{"date-parts":[[2006,5]]},"abstract":"<jats:title>Summary<\/jats:title>\n                  <jats:p>Mexico\u2010born women in the United States have an unexplained twofold increased risk of neural tube defect (NTD)\u2010affected pregnancies. We examined whether immigration characteristics were associated with the NTD risk and whether anthropometric factors contributed to the increased risk among Mexico\u2010born women. Data were derived from a large population\u2010based case\u2013control study in California. In\u2010person interviews were conducted with mothers of 538 (88% of eligible) NTD\u2010affected fetuses\/infants and mothers of 539 (88%) randomly selected non\u2010malformed control infants.<\/jats:p>\n                  <jats:p>\n                    The crude odds ratio (OR) for NTDs among all Mexico\u2010born women, women residing &lt;2\u2003years in the US, and women &gt;16\u2003years old at immigration compared with non\u2010Hispanic white women was 2.4 [95% confidence interval (CI)\u2003=\u20031.8, 3.3], 7.2 [95% CI\u2003=\u20033.7, 14.0] and 3.0 [95% CI\u2003=\u20032.0, 4.4], respectively. Risk for second\u2010 or third\u2010generation Mexican\u2010Americans was similar to that of white women. The crude OR for all Mexico\u2010born women was reduced from 2.4 to 2.0 [95% CI\u2003=\u20031.3, 3.0] and for those residing &lt;2\u2003years in the US from 8.4 to 7.1 [95% CI\u2003=\u20033.2, 15.3] after adjustment for maternal body mass index (BMI), height, compromised diet, diabetes, and other known risk factors. In term pregnancies, additional adjustment for pregnancy weight gain reduced the OR in all Mexico\u2010born women and recent immigrants by 16% and 25%, respectively. Low pregnancy weight gain (&lt;10 vs. 10\u201314\u2003kg) was particularly associated with increased NTD risk among Mexico\u2010born women (OR\n                    <jats:sub>ADJ<\/jats:sub>\n                    \u2003=\u20035.8; 95% CI\u2003=\u20032.1, 15.8).\n                  <\/jats:p>\n                  <jats:p>Findings indicate that recent Mexican immigrants have a sevenfold increased risk for NTDs. Maternal BMI and height contributed very little, and inadequate weight gain contributed modestly to the NTD risk disparity for Mexican immigrants.<\/jats:p>","DOI":"10.1111\/j.1365-3016.2006.00722.x","type":"journal-article","created":{"date-parts":[[2006,4,7]],"date-time":"2006-04-07T10:15:29Z","timestamp":1144404929000},"page":"219-230","source":"Crossref","is-referenced-by-count":29,"title":["Understanding the increased risk of neural tube defect\u2010affected pregnancies among Mexico\u2010born women in California: immigration and anthropometric factors"],"prefix":"10.1111","volume":"20","author":[{"given":"Ellen M.","family":"Velie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary M.","family":"Shaw","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine H.","family":"Malcoe","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donna M.","family":"Schaffer","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steven J.","family":"Samuels","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen","family":"Todoroff","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gladys","family":"Block","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2006,4,7]]},"reference":[{"key":"e_1_2_6_2_2","doi-asserted-by":"publisher","DOI":"10.1016\/0021-9681(82)90029-7"},{"key":"e_1_2_6_3_2","first-page":"17","article-title":"Leading major congenital malformations among minority groups in the United States, 1981\u201386","volume":"37","author":"Chavez G","year":"1988","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_6_4_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250309"},{"key":"e_1_2_6_5_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1469-8749.1983.tb13823.x"},{"key":"e_1_2_6_6_2","volume-title":"Anencephaly in Texas, Texas Vital Statistics, 1988","author":"Brender J","year":"1989"},{"key":"e_1_2_6_7_2","first-page":"33","article-title":"Epidemiology of anencephaly in Texas, 1981\u20131986","volume":"85","author":"Brender J","year":"1989","journal-title":"Texas Medicine"},{"key":"e_1_2_6_8_2","volume-title":"An Investigation of a Cluster of Neural Tube Defects in Cameron County, Texas.","author":"Texas Department of Health.","year":"1992"},{"key":"e_1_2_6_9_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420490210"},{"key":"e_1_2_6_10_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008647"},{"key":"e_1_2_6_11_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.87.9.1467"},{"key":"e_1_2_6_12_2","doi-asserted-by":"publisher","DOI":"10.1089\/109065799316572"},{"key":"e_1_2_6_13_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009766"},{"key":"e_1_2_6_14_2","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/152.11.1017"},{"key":"e_1_2_6_15_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420250308"},{"key":"e_1_2_6_16_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008653"},{"key":"e_1_2_6_17_2","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780192618849.001.0001","volume-title":"Epidemiology and Control of Neural Tube Defects","author":"Elwood J","year":"1992"},{"key":"e_1_2_6_18_2","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.88.11.1674"},{"key":"e_1_2_6_19_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-200111000-00009"},{"key":"e_1_2_6_20_2","doi-asserted-by":"publisher","DOI":"10.1016\/S1047-2797(02)00267-3"},{"key":"e_1_2_6_21_2","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10047"},{"key":"e_1_2_6_22_2","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000073270.39780.e9"},{"key":"e_1_2_6_23_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(94)70224-1"},{"key":"e_1_2_6_24_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530380035028"},{"key":"e_1_2_6_25_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.1996.03530380031027"},{"key":"e_1_2_6_26_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199609000-00010"},{"key":"e_1_2_6_27_2","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(94)00056-3"},{"key":"e_1_2_6_28_2","first-page":"205","volume-title":"Birth Defects: Risks and Consequences","author":"Stein Z","year":"1976"},{"key":"e_1_2_6_29_2","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/30.1.60"},{"key":"e_1_2_6_30_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(58)92062-2"},{"key":"e_1_2_6_31_2","doi-asserted-by":"publisher","DOI":"10.1139\/g62-010"},{"key":"e_1_2_6_32_2","doi-asserted-by":"crossref","unstructured":"MartorellR.Enhancing human potential in Guatemalan adults through improved nutrition in early childhood.Nutrition TodayJanuary February 1993;6\u201313.","DOI":"10.1097\/00017285-199301000-00003"},{"key":"e_1_2_6_33_2","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420080315"},{"key":"e_1_2_6_34_2","first-page":"73","article-title":"Special health problems of Mexican\u2010Americans: obesity, gallbladder disease, diabetes mellitus, and cardiovascular disease","volume":"34","author":"Diehl AK","year":"1989","journal-title":"Advances in International Medicine"},{"key":"e_1_2_6_35_2","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(97)00303-9"},{"key":"e_1_2_6_36_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a010059"},{"key":"e_1_2_6_37_2","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.1991.tb00728.x"},{"key":"e_1_2_6_38_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114416"},{"key":"e_1_2_6_39_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113439"},{"key":"e_1_2_6_40_2","volume-title":"Intercooled Version 4.0.","author":"STATA","year":"1995"},{"key":"e_1_2_6_41_2","volume-title":"Recommended Dietary Allowances","author":"National Research Council.","year":"1989"},{"key":"e_1_2_6_42_2","first-page":"1","volume-title":"Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report.","author":"National Institutes of Health, National Health, Lung and Blood Institute.","year":"1998"},{"key":"e_1_2_6_43_2","doi-asserted-by":"publisher","DOI":"10.1037\/028326"},{"key":"e_1_2_6_44_2","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008953"},{"key":"e_1_2_6_45_2","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4899-2575-6_7"},{"key":"e_1_2_6_46_2","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/62.5.1013"},{"key":"e_1_2_6_47_2","volume-title":"Rural Development: Problems and Progress of Colonia Subdivisions Near Mexico Border","author":"Community and Economic Development Division.","year":"1990"},{"key":"e_1_2_6_48_2","doi-asserted-by":"publisher","DOI":"10.1001\/jama.265.2.242"},{"key":"e_1_2_6_49_2","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(92)90302-7"},{"key":"e_1_2_6_50_2","doi-asserted-by":"publisher","DOI":"10.1097\/00001648-199710000-00002"}],"container-title":["Paediatric and Perinatal Epidemiology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fj.1365-3016.2006.00722.x","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/j.1365-3016.2006.00722.x","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,3]],"date-time":"2024-02-03T12:03:31Z","timestamp":1706961811000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/j.1365-3016.2006.00722.x"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2006,4,7]]},"references-count":49,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2006,5]]}},"alternative-id":["10.1111\/j.1365-3016.2006.00722.x"],"URL":"https:\/\/doi.org\/10.1111\/j.1365-3016.2006.00722.x","archive":["Portico"],"relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.14110.471613","asserted-by":"object"}]},"ISSN":["0269-5022","1365-3016"],"issn-type":[{"value":"0269-5022","type":"print"},{"value":"1365-3016","type":"electronic"}],"subject":[],"published":{"date-parts":[[2006,4,7]]}}}